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Pregled bibliografske jedinice broj: 733614

Androgens in post-menopausal patients with systemic sclerosis


Perković, Dijana; Martinović Kaliterna, Dušanka; Jurišić, Zrinka; Lalovac, Miloš; Radić, Mislav
Androgens in post-menopausal patients with systemic sclerosis // Rheumatology, 54 (2015), 4; 744-746 doi:10.1093/rheumatology/keu432 (međunarodna recenzija, pismo, znanstveni)


CROSBI ID: 733614 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Androgens in post-menopausal patients with systemic sclerosis

Autori
Perković, Dijana ; Martinović Kaliterna, Dušanka ; Jurišić, Zrinka ; Lalovac, Miloš ; Radić, Mislav

Izvornik
Rheumatology (1462-0324) 54 (2015), 4; 744-746

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo, znanstveni

Ključne riječi
systemic sclerosis ; sex hormones

Sažetak
Objectives. The aim of this study was to investigate the serum levels of estradiol, testosterone, dehydroepiandrosterone sulphate (DHEAS) and androstenedione in post-menopausal systemic sclerosis (SSc) patients and to examine the possible correlation with autoantibodies in SSc. Methods. Twenty-seven post-menopausal SSc patients and twenty-seven healthy women were enrolled in the study. Serum levels of estradiol, testosterone, androstenedione and DHEAS were measured in both groups. Serum levels of anticentromeric antibodies (ACA) and DNA topoisomerase I antibodies (anti-Scl 70) were measured only in SSc patients. Results: Serum levels of testosterone (0.80± 0.62 nmol/L v. 1.64±1.02 nmol/l, p<0.001), DHEAs (1.16±1.00 µmol/L v. 2.00±1.08 µmol/L, p=0.008) and androstenedione (3.26±3.08 nmol/L v. 5.79±2.82 nmol/L, p=0.004) were significantly lower in SSc patients compared to controls. There wasn't a significant difference in serum level of estradiol between groups (p=0.250). Serum levels of androstenedione negatively correlated with ACA antibodies (r=-0.434, p=0.024) while a positive correlation was found with the Scl-70 antibodies (r=0.385, p=0.047). Testosterone levels positively correlated with Scl-70 antibodies (r=0.489, p=0.010). Conclusion: Circulating testosterone, androstenedione and DHEAS levels are decreased in post-menopausal patients with SSc compared with healthy post- menopausal women. Our study contributed in recent cognitions on altered hormonal status in SSc patients. Negative correlation between androgen compounds androstendione and ACA support a protective anti- inflammatory role of androgen steroids in SSc. The positive correlation of androgens with Scl70 is confusing and needs further investigations.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
KBC Split,
Opća bolnica Dubrovnik

Poveznice na cjeloviti tekst rada:

doi academic.oup.com

Citiraj ovu publikaciju:

Perković, Dijana; Martinović Kaliterna, Dušanka; Jurišić, Zrinka; Lalovac, Miloš; Radić, Mislav
Androgens in post-menopausal patients with systemic sclerosis // Rheumatology, 54 (2015), 4; 744-746 doi:10.1093/rheumatology/keu432 (međunarodna recenzija, pismo, znanstveni)
Perković, D., Martinović Kaliterna, D., Jurišić, Z., Lalovac, M. & Radić, M. (2015) Androgens in post-menopausal patients with systemic sclerosis. Rheumatology, 54 (4), 744-746 doi:10.1093/rheumatology/keu432.
@article{article, author = {Perkovi\'{c}, Dijana and Martinovi\'{c} Kaliterna, Du\v{s}anka and Juri\v{s}i\'{c}, Zrinka and Lalovac, Milo\v{s} and Radi\'{c}, Mislav}, year = {2015}, pages = {744-746}, DOI = {10.1093/rheumatology/keu432}, keywords = {systemic sclerosis, sex hormones}, journal = {Rheumatology}, doi = {10.1093/rheumatology/keu432}, volume = {54}, number = {4}, issn = {1462-0324}, title = {Androgens in post-menopausal patients with systemic sclerosis}, keyword = {systemic sclerosis, sex hormones} }
@article{article, author = {Perkovi\'{c}, Dijana and Martinovi\'{c} Kaliterna, Du\v{s}anka and Juri\v{s}i\'{c}, Zrinka and Lalovac, Milo\v{s} and Radi\'{c}, Mislav}, year = {2015}, pages = {744-746}, DOI = {10.1093/rheumatology/keu432}, keywords = {systemic sclerosis, sex hormones}, journal = {Rheumatology}, doi = {10.1093/rheumatology/keu432}, volume = {54}, number = {4}, issn = {1462-0324}, title = {Androgens in post-menopausal patients with systemic sclerosis}, keyword = {systemic sclerosis, sex hormones} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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