engleski

Beneficial effect of oral creatine intake in the case of "Vacuolating megalencephalopathy with subcortical cysts"

We report on 7 years old boy with "Vacuolating megalencephalopathy with subcortical cysts" (van der Knaap 1995) who recived oral creatine 2g twice a day for two years. The boy had clinical, neurophychiological and MRI/MRS assessment at age of 5 yrs, showing at neurological examination mild ataxia, brisk tendon reflexes with ankle clonus, swallowing problems and dysarthric speech, as well as marked macrocephaly. Proton MRS examination showed reduced spectra of N-acetyl aspartic acid and creatine within altered white matter indicating axonal pathology and loss. Afterwords oral intake of creatine was started and continued onwards. At the age of 7 years the boy underwent MRI/MRS reexamination showing ameliorate findings which was in accordance with his intellectual prosgress and regression of some deviant neurological signs as well as stabilization of head growth.

Creatine; Megalencephalic leukoencephalopathy

nije evidentirano