engleski

Porphotetramethenes (Calix[4]pyrroletetraquinomethides) from oxidative N-alkylation of porphyrin tetraphenols

Air oxidation of porphyrin tetraphenols under basic conditions followed by N-alkylation readily provides tetrapyrrole macrocycles, in which the pyrroles are conected by sp^2 centers (as shown in the figure), in good yields. The reaction conditions were optimized to influence the degree of this one-pot reaction with different alkylation reagents. A number of partially, as well as mixed, N-substituted products were prepared. The yields obtained for certain products are a significant improvement as compared to earlier experiments by Milgrom et al. [J. Heterocycl. Chem. 32, 97 - 101 (1995)]

porphotetramethene; porphyrin; N-alkylation; tetrapyrrole

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