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Pregled bibliografske jedinice broj: 732956

Efficacy and safety of moxifloxacin in community acquired pneumonia:A prospective, multicenter, observational study (CAPRIVI)


Kuzman, Ilija; Bezlepko, Alexander; Topuzovska Tondova, Irena; Rokusz, Laszlo; Ludina, Ludmyla; Marschall, Hans-Peter; Petri, Thomas.
Efficacy and safety of moxifloxacin in community acquired pneumonia:A prospective, multicenter, observational study (CAPRIVI) // BMC Pulmonary Medicine, 14 (2014), 105-1 doi:10.1186/1471-2466-14-105 (međunarodna recenzija, članak, znanstveni)


Naslov
Efficacy and safety of moxifloxacin in community acquired pneumonia:A prospective, multicenter, observational study (CAPRIVI)

Autori
Kuzman, Ilija ; Bezlepko, Alexander ; Topuzovska Tondova, Irena ; Rokusz, Laszlo ; Ludina, Ludmyla ; Marschall, Hans-Peter ; Petri, Thomas.

Izvornik
BMC Pulmonary Medicine (1471-2466) 14 (2014); 105-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Antibiotics; Pneumonia; Community acquired; CAP; Moxifloxacin

Sažetak
CAPRIVI (Community Acquired Pneumonia: tReatment wIth AVelox® in hospItalized patients) was a prospective observational study in 12 countries: Croatia, France, Hungary, Kazakhstan, Jordan, Kyrgyzstan, Lebanon, Republic of Moldova, Romania, Russia, Ukraine, and Macedonia. Patients aged >18 years were treated with moxifloxacin 400 mg daily following hospitalization with a CAP diagnosis. In addition to efficacy and safety outcomes, data were collected on patient history and disease severity measured by CRB-65 score. 2733 patients were enrolled. A low severity index (i.e., CRB-65 score <2) was reported in 87.5% of CAP patients assessed (n = 1847), an unexpectedly high proportion for hospitalized patients. Moxifloxacin administered for a mean of 10.0 days (range: 2.0 to 39.0 days) was highly effective: 96.7% of patients in the efficacy population (n = 2152) improved and 93.2% were cured of infection during the study. Severity of infection changed from “moderate” or “severe” in 91.8% of patients at baseline to “no infection” or “mild” in 95.5% at last visit. In the safety population (n = 2595), 127 (4.9%) patients had treatment-emergent adverse events (TEAEs) and 40 (1.54%) patients had serious TEAEs ; none of these 40 patients died. The safety results were consistent with the known profile of moxifloxacin. The efficacy and safety profiles of moxifloxacin at the recommended dose of 400 mg daily are characterized in this large observational study of hospitalized CAP patients from Eastern and Central Europe and the Middle East. The high response rate in this study, which included patients with a range of disease severities, suggests that treatment with broader-spectrum drugs such as moxifloxacin is appropriate for patients with CAP who are managed in hospital

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-0000000-3491 - ISTRAŽIVANJE ETIOLOGIJE I PATOGENEZE PNEUMONIJA (Ilija Kuzman, )

Ustanove
Medicinski fakultet, Zagreb

Autor s matičnim brojem:
Ilija Kuzman, (142373)

Citiraj ovu publikaciju

Kuzman, Ilija; Bezlepko, Alexander; Topuzovska Tondova, Irena; Rokusz, Laszlo; Ludina, Ludmyla; Marschall, Hans-Peter; Petri, Thomas.
Efficacy and safety of moxifloxacin in community acquired pneumonia:A prospective, multicenter, observational study (CAPRIVI) // BMC Pulmonary Medicine, 14 (2014), 105-1 doi:10.1186/1471-2466-14-105 (međunarodna recenzija, članak, znanstveni)
Kuzman, I., Bezlepko, A., Topuzovska Tondova, I., Rokusz, L., Ludina, L., Marschall, H. & Petri, T. (2014) Efficacy and safety of moxifloxacin in community acquired pneumonia:A prospective, multicenter, observational study (CAPRIVI). BMC Pulmonary Medicine, 14, 105-1 doi:10.1186/1471-2466-14-105.
@article{article, year = {2014}, pages = {105-1-105-14}, DOI = {10.1186/1471-2466-14-105}, keywords = {Antibiotics, Pneumonia, Community acquired, CAP, Moxifloxacin}, journal = {BMC Pulmonary Medicine}, doi = {10.1186/1471-2466-14-105}, volume = {14}, issn = {1471-2466}, title = {Efficacy and safety of moxifloxacin in community acquired pneumonia:A prospective, multicenter, observational study (CAPRIVI)}, keyword = {Antibiotics, Pneumonia, Community acquired, CAP, Moxifloxacin} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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