engleski

Clinico-pathologic characteristics of breast cancer in young women: Croatian single institution expirience

Introduction: According to the data provided by Croatian National Cancer Registry for 2011, there were 2094 new cases of breast cancer in Croatia. That number represents 22% of all newly diagnosed cases making it most common cancer site in Croatian women. Aim. The aim of this study was to analyse clinicopathologic prognostic factors of breast cancer in patients younger than 40 in the cohort of single institution Croatian breast cancer patients. Materials and methods. Breast cancer paraffin- embedded tissue specimens were obtained from a consecutive retrospective series of 215 female patients with primary invasive tumors referred to the University Hospital Center Zagreb, Croatia, between September, 2002 and September 2003. Median of age at diagnosis was 56 years (min 30, max 87). Median of follow up is 9.38 years (min 8 months, max 10.4 years). 135 pts. were menopausal at diagnosis. All pts. were diagnosed by pathohistological examination of extirpated tumor including immunohistochemistry (IHC) for estrogen (ER) and progesterone (PR) receptor, as well as Her-2 and Ki-67 determination. Her-2/neu confirming methods were FISH or CISH for suspected amplification (++ by IHC). Surogate biological subtypes were defined according to primary tumour IHC analyses according to St Gallen Consensus Conference recommendations. Results: Median of age at diagnosis of whole cohort was 56 years (min 30, max 87). Among 215 patients, thirteen of them (6.04%) were younger than 40 in the time of diagnosis, thus fullfilling criteria for breast cancer in young subgroup (BCY). In the premenopausal subgroup they had share of 16.3%, and 6.04% share in whole cohort of breast cancer patients. More than a third of the tumours were classified as luminal B like surogat subtype (5 tumours or 38.5%), 3 of 13, or 23.1% were luminal A like, and, finally, more than one third were triple negative like (5 of 13, or 38.5%). Compared with whole cohort, triple-negative like subtype was more often in younger than 40 subgroup (24.2% vs 38.5%). In the almost 10-years follow-up 53.8% of patients in BCY subgroup have relapsed, compaired with 30.2% patients with locoregional and/or distant relaps in whole cohort. Similarly, 30.8% of patients in BCY subgroup have died compaired with 20.6% died in whole cohort. Conclusions: Subgroup of patients younger than 40 in breast cancer cohort represents those who tend to have a triple negative subtype, they are more prone to locoregional and/or distant relaps, and more prone to death from breast cancer.

breast cancer; young women

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