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MCMV avoidance of recognition and control by NK cells


Brizić, Ilija; Lenac Roviš, Tihana; Krmpotić, Astrid; Jonjić, Stipan
MCMV avoidance of recognition and control by NK cells // Seminars in immunopathology, 36 (2014), 6; 641-650 doi:10.1007/s00281-014-0441-9 (međunarodna recenzija, članak, znanstveni)


Naslov
MCMV avoidance of recognition and control by NK cells

Autori
Brizić, Ilija ; Lenac Roviš, Tihana ; Krmpotić, Astrid ; Jonjić, Stipan

Izvornik
Seminars in immunopathology (1863-2297) 36 (2014), 6; 641-650

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
MCMV ; NK cell receptors ; Immune evasion ; memory NK cells ; CMV vaccine vector ; NK cell-T cell crosstalk

Sažetak
Natural killer (NK) cells play an important role in virus control during infection. Many viruses have developed mechanisms for subversion of NK cell responses. Murine cytomegalovirus (MCMV) is exceptionally successful in avoiding NK cell control. Here, we summarize the major MCMV evasion mechanisms targeting NK cell functions and their role in viral pathogenesis. The mechanisms by which NK cells regulate CD8(+) T cell response, particularly with respect to the role of NK cell receptors recognizing viral antigens, are discussed. In addition, we discuss the role of NK cell receptors in generation and maintenance of memory NK cells. Final part of this review illustrates how the NK cell response and its viral regulation can be exploited in designing recombinant viral vectors able to induce robust and protective CD8(+) T cell response.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Stipan Jonjić, )
062-0621261-1268 - Uloga imunosubverzivnih citomegalovirusnih gena u latenciji (Astrid Krmpotić, )

Ustanove
Medicinski fakultet, Rijeka

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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