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Pregled bibliografske jedinice broj: 732057

Classical medications in the treatment of inflammatory bowel diseases


Duvnjak, Marko; Bilić, Ante; Baršić, Neven; Tomašić, Vedran; Stojsavljević, Sanja
Classical medications in the treatment of inflammatory bowel diseases // Acta Medica Croatica, 67 (2013), 111-123 (podatak o recenziji nije dostupan, članak, ostalo)


CROSBI ID: 732057 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Classical medications in the treatment of inflammatory bowel diseases

Autori
Duvnjak, Marko ; Bilić, Ante ; Baršić, Neven ; Tomašić, Vedran ; Stojsavljević, Sanja

Izvornik
Acta Medica Croatica (1330-0164) 67 (2013); 111-123

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
Crohn’s disease; ulcerative colitis; aminosalicylates; azathioprine; corticosteroids; 6-mercaptopurine; methotrexate; cyclosporine; antibiotics

Sažetak
The treatment of inflammatory bowel diseases is complex and requires individual approach to every single patient. Traditionally, the approach is based on introduction of so called ‘’classical’’ medication into the treatment regimen, from ones less potent and with fewer side effects to the ones more toxic but also therapeutically more effective. Aminosalicylates were the first choice of treatment for a long time. However, the role of aminosalicylates is becoming more and more diminished, although they are still the drug of choice in the treatment of mild to moderate ulcerative colitis. Corticosteroids are the therapy of choice in treatment of active IBD for achieving remission in moderate to severe disease. Azathioprine and 6- mercaptopurine belong to a group of thiopurines with an immunomodulatory effect which, in Crohn’s disease as well as in ulcerative colitis, primarily have a role in a steroid dependant or steroid refractory type of disease and in maintenance of remission. Lately, early introduction of these medications is proposed to enhance the number of patients that remain in remission. Methotrexate is used for the therapy of active and relapsing Crohn’s disease and represents an alternative in patients who do not tolerate or do not respond to azathioprine or 6-mercaptopurine therapy. Cyclosporine is used in treating steroid refractory ulcerative colitis and in some patients can postpone the need for colectomy. Antibiotics do not have a proven effect on the course of inflammatory bowel diseases and their primary role is to treat septic complications. Classic medications today represent a standard in the management of inflammatory bowel diseases, and the combination of the previously mentioned drugs often has a more potent effect on the course of the disease than any medication on its own and their combination is still an object of investigations and clinical studies.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Profili:

Avatar Url Ante Bilić (autor)

Avatar Url Vedran Tomašić (autor)

Avatar Url Neven Baršić (autor)

Avatar Url Marko Duvnjak (autor)


Citiraj ovu publikaciju:

Duvnjak, Marko; Bilić, Ante; Baršić, Neven; Tomašić, Vedran; Stojsavljević, Sanja
Classical medications in the treatment of inflammatory bowel diseases // Acta Medica Croatica, 67 (2013), 111-123 (podatak o recenziji nije dostupan, članak, ostalo)
Duvnjak, M., Bilić, A., Baršić, N., Tomašić, V. & Stojsavljević, S. (2013) Classical medications in the treatment of inflammatory bowel diseases. Acta Medica Croatica, 67, 111-123.
@article{article, author = {Duvnjak, Marko and Bili\'{c}, Ante and Bar\v{s}i\'{c}, Neven and Toma\v{s}i\'{c}, Vedran and Stojsavljevi\'{c}, Sanja}, year = {2013}, pages = {111-123}, keywords = {Crohn’s disease, ulcerative colitis, aminosalicylates, azathioprine, corticosteroids, 6-mercaptopurine, methotrexate, cyclosporine, antibiotics}, journal = {Acta Medica Croatica}, volume = {67}, issn = {1330-0164}, title = {Classical medications in the treatment of inflammatory bowel diseases}, keyword = {Crohn’s disease, ulcerative colitis, aminosalicylates, azathioprine, corticosteroids, 6-mercaptopurine, methotrexate, cyclosporine, antibiotics} }
@article{article, author = {Duvnjak, Marko and Bili\'{c}, Ante and Bar\v{s}i\'{c}, Neven and Toma\v{s}i\'{c}, Vedran and Stojsavljevi\'{c}, Sanja}, year = {2013}, pages = {111-123}, keywords = {Crohn’s disease, ulcerative colitis, aminosalicylates, azathioprine, corticosteroids, 6-mercaptopurine, methotrexate, cyclosporine, antibiotics}, journal = {Acta Medica Croatica}, volume = {67}, issn = {1330-0164}, title = {Classical medications in the treatment of inflammatory bowel diseases}, keyword = {Crohn’s disease, ulcerative colitis, aminosalicylates, azathioprine, corticosteroids, 6-mercaptopurine, methotrexate, cyclosporine, antibiotics} }

Časopis indeksira:


  • Scopus
  • MEDLINE





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