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Pregled bibliografske jedinice broj: 731883

Novel locus for fibrinogen in 3' region of LEPR gene in island population of Vis (Croatia)


Tomas, Željka; Zajc Petranović, Matea; Škarić-Jurić, Tatjana; Barešić, Ana; Peričić Salihović, Marijana; Smolej Narančić, Nina
Novel locus for fibrinogen in 3' region of LEPR gene in island population of Vis (Croatia) // Journal of human genetics, 59 (2014), 11; 623-629 doi:10.1038/jhg.2014.82 (međunarodna recenzija, članak, znanstveni)


Naslov
Novel locus for fibrinogen in 3' region of LEPR gene in island population of Vis (Croatia)

Autori
Tomas, Željka ; Zajc Petranović, Matea ; Škarić-Jurić, Tatjana ; Barešić, Ana ; Peričić Salihović, Marijana ; Smolej Narančić, Nina

Izvornik
Journal of human genetics (1434-5161) 59 (2014), 11; 623-629

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Leptin receptor gene (LEPR); linkage disequilibrium (LD); haplotype; CVD risk factors; Single Nucleotide Polymorphisms (SNP)

Sažetak
Leptin, a possible mediator between energy homeostasis, inflammation and cardiovascular disease (CVD), acts via leptin receptors. We investigated association of single-nucleotide polymorphisms (SNPs) and haplotypes of the leptin receptor gene (LEPR) with several CVD risk factors: body mass index, waist circumference (WC), serum lipids, fibrinogen and C-reactive protein levels. Thirty-one SNPs in and near LEPR gene were analyzed in 986 inhabitants of the island of Vis, Croatia and 29 SNPs in the inland sample (N=499). We assessed linkage disequilibrium (LD), SNP and haplotype associations with the selected phenotypes. rs4291477 significantly associated with fibrinogen (P=0.003) and rs7539471 marginally significantly with high-density lipoprotein (P=0.004), but only in the Vis sample, while rs10493384 marginally significantly associated with triglyceride levels (P=0.006) in the inland sample. SNPs were grouped into eight LD blocks in Vis and in seven blocks in the inland population. Haplotype A-C-A-A-G-A in block 5 in Vis (rs1782754, rs1171269, rs1022981, rs6673324, rs3790426, rs10493380) and haplotype A-A-A-A in block 4 in the inland data (rs1782754, rs1022981, rs6673324, rs1137100) were nominally associated with WC, P=7.085 × 10-22 (adjusted P=0.0979) and P=5.496 × 10-144 (adjusted P=0.1062), respectively.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Javno zdravstvo i zdravstvena zaštita, Etnologija i antropologija



POVEZANOST RADA


Projekt / tema
196-1962766-2736 - Stohastički i kibernetički modeli u antropologiji (Tatjana Škarić-Jurić, )
196-1962766-2747 - Kompleksna obilježja i zdravlje stanovništva od djetinjstva do duboke starosti (Nina Smolej-Narančić, )
196-1962766-2763 - Molekularno-genetička obilježja populacija utemeljitelja - Romi kao model (Branka Janićijević, )

Ustanove
Institut za antropologiju

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Abstracts in Anthropology
  • Biological Sciences
  • BIOSIS Previews (Biological Abstracts)
  • Calcium and Calcified Tissue Abstracts
  • Chemoreception Abstracts
  • EMBASE (Excerpta Medica)
  • Genetics Abstracts
  • MEDLINE
  • Academic Search
  • Biotechnology Citation Indeks
  • CSA Neurosciences Abstracts
  • Elsevier Biobase
  • Global Health
  • Google Scholar
  • PubMed
  • Scopus


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