engleski

Biological activity of extracts from selected Asteraceae plant species

Croatia flora is rich with plant species from Asteraceae familiy. Some of these species are well known medicinal plants, widely used in ethnomedicine. Since the substances used in treatment of some diseases are potentially harmful for human health, it is challenge to find active substances of natural origin like medicinal plants. Alzheimer disease (AD) is an incurable form of dementia which causes severe cognitive dysfunctions. AD is manifested as reduction of neurotransmitter acetylcholine inside the cholinergic system, hence the inhibition of acetylcholinesterase (AChE), enzyme that hydrolyses acetylcholine, has an important role in AD treatment. It is also considered that oxidative stress could be a trigger for AD development ; hence the research of AChE inhibitors is accompanied by assessment of their antioxidative activity. The aim of this work was to test AChE inhibitory activity as well as antioxidative activity of extracts from selected Asteraceae species: <i>Centaurea ragusina</i> L., <i>Inula verbascifolia</i> (Willd.) Hausskn and <i>Pallenis spinosa</i> (Cass.) Cass.

Alzheimer; acetylcholinesterase; inhibition; antioxidation; <i>Centaurea ragusina</i>; <i>Inula verbascifolia</i>; <i>Pallenis spinosa</i>

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