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Pregled bibliografske jedinice broj: 730888

Epigenetic activation of immune genes in cervical cancer


Milutin Gašperov, Nina; Farkas, Sanja A; Nilsson, Torbjorn K; Grce, Magdalena
Epigenetic activation of immune genes in cervical cancer // Immunology letters, 14 (2014), S0165; 1-2 doi:10.1016/j.imlet.2014.09.019 (podatak o recenziji nije dostupan, pismo uredniku, znanstveni)


Naslov
Epigenetic activation of immune genes in cervical cancer

Autori
Milutin Gašperov, Nina ; Farkas, Sanja A ; Nilsson, Torbjorn K ; Grce, Magdalena

Izvornik
Immunology letters (0165-2478) 14 (2014), S0165; 1-2

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo uredniku, znanstveni

Ključne riječi
Immune; cancer; HPV; gene; hypomethylation

Sažetak
Immune system provides us protection from infectious pathogens and tumors formation during lifetime. Cervical cancer (CC), and its cause, human papillomavirus (HPV) are both challenges for the immune system. We present here evidence of epigenetic activation of immune system genes in CC. Illumina Infinium Human Methylation 450K BeadChip identified genes, which were all significantly hypomethylated in CC tissue versus normal tissue. The GeneMANIA computer program identified a tight network between those genes. The most strongly correlated genes based on their function are immune effectors' process (AIM2, BST2, BTN3A3, and IL12RB1) and response to virus related genes (AIM2, BST2, and IL12RB1). Thus, activation of those genes through demethylation is probably triggered by HPV oncogenes. In conclusion, the immune system of women who do not develop CC is probably activated earlier through DNA demethylation.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2510 - Promijenjeno stanje DNA-metilacije u HPV-povezanim oštećenjima (Magdalena Grce, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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