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Pregled bibliografske jedinice broj: 730538

HLA allele and haplotype polymorphisms among Croatian patients in an unrelated hematopoietic stem cell donor search program


Grubić, Zorana; Štingl, Katarina; Maskalan, Marija; Serventi-Seiwerth, Ranka; Mikulić, Mirta; Burek Kamenarić, Marija; Nemet, Damir; Žunec, Renata
HLA allele and haplotype polymorphisms among Croatian patients in an unrelated hematopoietic stem cell donor search program // Transplant immunology, 31 (2014), 3; 119-124 doi:10.1016/j.trim.2014.06.007 (međunarodna recenzija, članak, znanstveni)


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Naslov
HLA allele and haplotype polymorphisms among Croatian patients in an unrelated hematopoietic stem cell donor search program

Autori
Grubić, Zorana ; Štingl, Katarina ; Maskalan, Marija ; Serventi-Seiwerth, Ranka ; Mikulić, Mirta ; Burek Kamenarić, Marija ; Nemet, Damir ; Žunec, Renata

Izvornik
Transplant immunology (0966-3274) 31 (2014), 3; 119-124

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Unrelated HSCT ; HLA ; Matching donor ; Searching protocol ; DRB1*11

Sažetak
Aim of the present study was to investigate HLA alleles and haplotypes among Croatian patients in unrelated HSCT program, and to analyze HLA matching in patient/donor pairs. Analysis was performed on a group of 105 patients and their donors, as control served 4000 unrelated donors from our Registry (CBMDR). PCR-SSO and PCR-SSP high-resolution methods for HLA-A, -B, -C, - DRB1, and -DQB1 loci were used for typing patient/donor pairs. Donors from CBMDR were tested for HLA-A, -B, -DRB1 by PCR-SSO. No difference was observed in frequency at HLA tested loci among patients and donors from CBMDR. Fully matched donor (10/10) was found for 68 (64.8%) patients, the highest number of mismatches was found for HLA-DRB1 and HLA-C alleles. The presence of HLA-B alleles (B*15:01, B*18:01, and B*51:01) associated with two or more HLA-C alleles as well as the presence of unusual HLA-B/HLA-C (B*35:01- C*07:01 and B*35:01-C*07:02) combinations resulted in mismatches at HLA-C locus. Additionally, mismatches at DRB1 locus were in most cases found for DRB1*11 alleles. The results suggest that the DRB1*11:04 allele might be considered as a limiting factor in finding a 10/10 matched donor. These data may help in the improvement of the searching protocol for unrelated donors for Croatian patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-1081872-2061 - LIMFOPROLIFERATIVNE BOLESTI I TRANSPLANTACIJA KRVOTVORNIH MATIČNIH STANICA (Damir Nemet, )
214-0000000-3573 - Uloga gena non-HLA u transplantaciji tkiva i organa (Renata Žunec, )
214-0000000-3354 - ISTRAŽIVANJA MIKROSATELITA UNUTAR REGIJE GLAVNOG SUSTAVA TKIVNE PODUDARNOSTI (Zorana Grubić, )

Ustanove
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb,
Sveučilište Libertas

Citiraj ovu publikaciju

Grubić, Zorana; Štingl, Katarina; Maskalan, Marija; Serventi-Seiwerth, Ranka; Mikulić, Mirta; Burek Kamenarić, Marija; Nemet, Damir; Žunec, Renata
HLA allele and haplotype polymorphisms among Croatian patients in an unrelated hematopoietic stem cell donor search program // Transplant immunology, 31 (2014), 3; 119-124 doi:10.1016/j.trim.2014.06.007 (međunarodna recenzija, članak, znanstveni)
Grubić, Z., Štingl, K., Maskalan, M., Serventi-Seiwerth, R., Mikulić, M., Burek Kamenarić, M., Nemet, D. & Žunec, R. (2014) HLA allele and haplotype polymorphisms among Croatian patients in an unrelated hematopoietic stem cell donor search program. Transplant immunology, 31 (3), 119-124 doi:10.1016/j.trim.2014.06.007.
@article{article, year = {2014}, pages = {119-124}, DOI = {10.1016/j.trim.2014.06.007}, keywords = {Unrelated HSCT, HLA, Matching donor, Searching protocol, DRB1\ast11}, journal = {Transplant immunology}, doi = {10.1016/j.trim.2014.06.007}, volume = {31}, number = {3}, issn = {0966-3274}, title = {HLA allele and haplotype polymorphisms among Croatian patients in an unrelated hematopoietic stem cell donor search program}, keyword = {Unrelated HSCT, HLA, Matching donor, Searching protocol, DRB1\ast11} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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