Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 730515

Composition of free fatty acids in the placenta of pregnant women with type 1 diabetes


Starčević, Vito; Delaš, Ivančica; Dražić, Tonko; Juras, Josip; Đelmiš, Josip
Composition of free fatty acids in the placenta of pregnant women with type 1 diabetes // The Interplay of Biomolecules / Katalinić, Maja ; Kovarik, Zrinka (ur.).
Zagreb: Croatian Society of Biochemistry and Molecular Biology, 2014. str. 85-85 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 730515 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Composition of free fatty acids in the placenta of pregnant women with type 1 diabetes

Autori
Starčević, Vito ; Delaš, Ivančica ; Dražić, Tonko ; Juras, Josip ; Đelmiš, Josip

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The Interplay of Biomolecules / Katalinić, Maja ; Kovarik, Zrinka - Zagreb : Croatian Society of Biochemistry and Molecular Biology, 2014, 85-85

ISBN
978-953-95551-5-1

Skup
Congress of the Croatian Society of Biochemistry and Molecular Biology

Mjesto i datum
Zadar, Hrvatska, 24-27. 09. 2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
free fatty acids; pregnancy; type 1 diabetes; placenta

Sažetak
INTRODUCTION Diabetes-induced changes and poorly regulated glycemia in diabetic pregnant women are reflected on placental tissue and metabolism, and consequently induce a series of complications in both the embryo and later fetus, and the pregnant woman. For normal growth and development of the fetal central nervous system of particular importance is the availability and supplementation of essential long-chain polyunsaturated fatty acids. The purpose of this study was to determine how changes in carbohydrate metabolism can affect the lipid content of the placenta in pregnant women with type 1 diabetes mellitus (DM 1). MATERIALS AND METHODS Pregnant women (38 with DM 1, and 34 healthy) were recruited for the study at the Reference Center for Diabetes in Pregnancy, Department of Gynecology and Obstetrics, Clinical Hospital Center Zagreb. All pregnancies were finished by caesarean section at the expected term of birth. Samples were collected from placental tissue, homogenized and total lipids were extracted by solvent mixtures. Free fatty acids were separated by thin layer chromatography, trans-esterified to methyl esters and analyzed by gas chromatography. RESULTS The amounts of free fatty acids were significantly reduced in placental tissue of the pregnant women with DM1 than in the control group. In DM1 group the ratio of lauric acid (C12:0) was significantly lower and the ratios of miristoleic (14:1), palmitic (16:0), stearic (18:0), oleic (18:1), linoleic (18:2) and docosahexaenoic (22:6) fatty acids were significantly higher than in the control group. CONCLUSION Decreased amounts of free fatty acids in the placenta of pregnant women with DM1 might indicate an increased lipolytic activity. Well regulated DM1 results with stable metabolism of carbohydrates and lipids, and with the appropriate fatty acid composition.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
0108068
108-1080401-0386 - Metaboličke i endokrine promjene u dijabetičnih trudnica (Josip Đelmiš, )
108-1080401-0385 - Dijabetes i metabolički sindrom nakon prethodnog gestacijskog dijabetesa (Marina Ivanišević, )

Ustanove
Medicinski fakultet, Zagreb

Profili:

Avatar Url Josip Đelmiš (autor)

Avatar Url Ivančica Delaš (autor)

Avatar Url Josip Juras (autor)

Avatar Url Vito Starčević (autor)

Citiraj ovu publikaciju

Starčević, Vito; Delaš, Ivančica; Dražić, Tonko; Juras, Josip; Đelmiš, Josip
Composition of free fatty acids in the placenta of pregnant women with type 1 diabetes // The Interplay of Biomolecules / Katalinić, Maja ; Kovarik, Zrinka (ur.).
Zagreb: Croatian Society of Biochemistry and Molecular Biology, 2014. str. 85-85 (poster, međunarodna recenzija, sažetak, znanstveni)
Starčević, V., Delaš, I., Dražić, T., Juras, J. & Đelmiš, J. (2014) Composition of free fatty acids in the placenta of pregnant women with type 1 diabetes. U: Katalinić, M. & Kovarik, Z. (ur.)The Interplay of Biomolecules.
@article{article, year = {2014}, pages = {85-85}, keywords = {free fatty acids, pregnancy, type 1 diabetes, placenta}, isbn = {978-953-95551-5-1}, title = {Composition of free fatty acids in the placenta of pregnant women with type 1 diabetes}, keyword = {free fatty acids, pregnancy, type 1 diabetes, placenta}, publisher = {Croatian Society of Biochemistry and Molecular Biology}, publisherplace = {Zadar, Hrvatska} }




Contrast
Increase Font
Decrease Font
Dyslexic Font