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Pregled bibliografske jedinice broj: 729951

Characteristics and outcomes of children with primary oxalosis requiring renal replacement therapy


Harambat, J; ...; Batinić, Danica; Jager, Mario; Kramar, Miroslav; Kramer, Erika; Paripović, Đuro; ...; Inward, C.
Characteristics and outcomes of children with primary oxalosis requiring renal replacement therapy // Clinical journal of american society of nephrology, 7 (2012), 3; 458-465 doi:10.2215/CJN.07430711 (međunarodna recenzija, članak, znanstveni)


Naslov
Characteristics and outcomes of children with primary oxalosis requiring renal replacement therapy

Autori
Harambat, J ; ... ; Batinić, Danica ; Jager, Mario ; Kramar, Miroslav ; Kramer, Erika ; Paripović, Đuro ; ... ; Inward, C.

Izvornik
Clinical journal of american society of nephrology (1555-9041) 7 (2012), 3; 458-465

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Children with primary oxalosis renal replacement therapy

Sažetak
Primary hyperoxaluria (PH) as a cause of ESRD in children is believed to have poor outcomes. Data on management and outcomes of these children remain scarce. This study included patients aged <19 years who started renal replacement therapy (RRT) between 1979 and 2009 from 31 countries providing data to a large European registry. Of 9247 incident patients receiving RRT, 100 patients had PH. PH children were significantly younger than non-PH children at the start of RRT. The median age at RRT of PH children decreased from 9.8 years in 1979-1989 to 1.5 years in 2000-2009. Survival was 86%, 79%, and 76% among PH patients at 1, 3, and 5 years after the start of RRT, compared with 97%, 94%, and 92% in non-PH patients, resulting in a three-fold increased risk of death over non-PH patients. PH and non-PH patient survival improved over time. Sixty-eight PH children received a first kidney (n=13) or liver-kidney transplantation (n=55). Although the comparison was hampered by the lower number of kidney transplantations primarily derived from the earlier era of RRT, kidney graft survival in PH patients was 82%, 79%, and 76% at 1, 3, and 5 years for liver-kidney transplantation and 46%, 28%, and 14% at 1, 3, and 5 years for kidney transplantation alone, compared with 95%, 90%, and 85% in non-PH patients. The outcomes of PH children with ESRD are still poorer than in non-PH children but have substantially improved over time.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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