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Combining [Arene–Ru] with Azocarboxamide to Generate a Complex with Cytotoxic Properties


Sommer, Michael; Kureljak, Petra; Urankar, Damijana; Schweinfurth, David; Stojanović, Nikolina; Bubrin, Martina; Gazvoda, Martin; Osmak, Maja; Sarkar, Biprajit; Košmrlj, Janez
Combining [Arene–Ru] with Azocarboxamide to Generate a Complex with Cytotoxic Properties // Chemistry : a European journal, 20 (2014), 52; 17296-17299 doi:10.1002/chem.201404448 (međunarodna recenzija, članak, znanstveni)


Naslov
Combining [Arene–Ru] with Azocarboxamide to Generate a Complex with Cytotoxic Properties

Autori
Sommer, Michael ; Kureljak, Petra ; Urankar, Damijana ; Schweinfurth, David ; Stojanović, Nikolina ; Bubrin, Martina ; Gazvoda, Martin ; Osmak, Maja ; Sarkar, Biprajit ; Košmrlj, Janez

Izvornik
Chemistry : a European journal (0947-6539) 20 (2014), 52; 17296-17299

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Azocarboxamide; N; N ligands; N; O ligands; Ruthenium; Cancer

Sažetak
Azocarboxamide (azcH) has been combined for the first time with [Ru–Cym] to generate metal complexes with N, N- and N, O-coordination mode, [(Cym)Ru(azc)Cl] and [(Cym)Ru(azcH)Cl]+[PF6]. Geometric and electronic structures of the complexes are reported along with their in vitro activities against different tumour cell lines and preliminary results on solution chemistry.Compound [(Cym)Ru(azc)Cl] exhibited remarkable cytotoxic properties. It was cell-type specific and had comparable IC50 values towards both cancer cells and their drug-resistant subline. A tenfold increase in the sensitivity towards[(Cym)Ru(azc)Cl] was noted for the tumour cells with depleted intracellular glutathione (GSH) level, suggesting the essential role of GSH in cell response to this compound.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekt / tema
098-0982913-2748 - Stanični odgovor na citotoksične spojeve i razvoj otpornosti (Maja Osmak, )
098-0982913-2850 - Povećanje transdukcije adenovirusnih vektora i otpornost stanica na citostatike (Andreja Ambriović Ristov, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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