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Pregled bibliografske jedinice broj: 728951

Combining [Arene–Ru] with Azocarboxamide to Generate a Complex with Cytotoxic Properties


Sommer, Michael; Kureljak, Petra; Urankar, Damijana; Schweinfurth, David; Stojanović, Nikolina; Bubrin, Martina; Gazvoda, Martin; Osmak, Maja; Sarkar, Biprajit; Košmrlj, Janez
Combining [Arene–Ru] with Azocarboxamide to Generate a Complex with Cytotoxic Properties // Chemistry : a European journal, 20 (2014), 52; 17296-17299 doi:10.1002/chem.201404448 (međunarodna recenzija, članak, znanstveni)


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Naslov
Combining [Arene–Ru] with Azocarboxamide to Generate a Complex with Cytotoxic Properties

Autori
Sommer, Michael ; Kureljak, Petra ; Urankar, Damijana ; Schweinfurth, David ; Stojanović, Nikolina ; Bubrin, Martina ; Gazvoda, Martin ; Osmak, Maja ; Sarkar, Biprajit ; Košmrlj, Janez

Izvornik
Chemistry : a European journal (0947-6539) 20 (2014), 52; 17296-17299

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Azocarboxamide; N; N ligands; N; O ligands; Ruthenium; Cancer

Sažetak
Azocarboxamide (azcH) has been combined for the first time with [Ru–Cym] to generate metal complexes with N, N- and N, O-coordination mode, [(Cym)Ru(azc)Cl] and [(Cym)Ru(azcH)Cl]+[PF6]. Geometric and electronic structures of the complexes are reported along with their in vitro activities against different tumour cell lines and preliminary results on solution chemistry.Compound [(Cym)Ru(azc)Cl] exhibited remarkable cytotoxic properties. It was cell-type specific and had comparable IC50 values towards both cancer cells and their drug-resistant subline. A tenfold increase in the sensitivity towards[(Cym)Ru(azc)Cl] was noted for the tumour cells with depleted intracellular glutathione (GSH) level, suggesting the essential role of GSH in cell response to this compound.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekti:
098-0982913-2748 - Stanični odgovor na citotoksične spojeve i razvoj otpornosti (Osmak, Maja, MZOS ) ( POIROT)
098-0982913-2850 - Povećanje transdukcije adenovirusnih vektora i otpornost stanica na citostatike (Ambriović Ristov, Andreja, MZOS ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Nikolina Stojanović (autor)

Avatar Url Maja Osmak (autor)

Citiraj ovu publikaciju

Sommer, Michael; Kureljak, Petra; Urankar, Damijana; Schweinfurth, David; Stojanović, Nikolina; Bubrin, Martina; Gazvoda, Martin; Osmak, Maja; Sarkar, Biprajit; Košmrlj, Janez
Combining [Arene–Ru] with Azocarboxamide to Generate a Complex with Cytotoxic Properties // Chemistry : a European journal, 20 (2014), 52; 17296-17299 doi:10.1002/chem.201404448 (međunarodna recenzija, članak, znanstveni)
Sommer, M., Kureljak, P., Urankar, D., Schweinfurth, D., Stojanović, N., Bubrin, M., Gazvoda, M., Osmak, M., Sarkar, B. & Košmrlj, J. (2014) Combining [Arene–Ru] with Azocarboxamide to Generate a Complex with Cytotoxic Properties. Chemistry : a European journal, 20 (52), 17296-17299 doi:10.1002/chem.201404448.
@article{article, year = {2014}, pages = {17296-17299}, DOI = {10.1002/chem.201404448}, keywords = {Azocarboxamide, N, N ligands, N, O ligands, Ruthenium, Cancer}, journal = {Chemistry : a European journal}, doi = {10.1002/chem.201404448}, volume = {20}, number = {52}, issn = {0947-6539}, title = {Combining [Arene–Ru] with Azocarboxamide to Generate a Complex with Cytotoxic Properties}, keyword = {Azocarboxamide, N, N ligands, N, O ligands, Ruthenium, Cancer} }
@article{article, year = {2014}, pages = {17296-17299}, DOI = {10.1002/chem.201404448}, keywords = {Azocarboxamide, N, N ligands, N, O ligands, Ruthenium, Cancer}, journal = {Chemistry : a European journal}, doi = {10.1002/chem.201404448}, volume = {20}, number = {52}, issn = {0947-6539}, title = {Combining [Arene–Ru] with Azocarboxamide to Generate a Complex with Cytotoxic Properties}, keyword = {Azocarboxamide, N, N ligands, N, O ligands, Ruthenium, Cancer} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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