engleski

Osteoporosis in the syndrome of ACTH insensitivity associated with nervous system disorders

Six children from 3 families with ACTH insensitivity and associated nervous system disorders are described. Five of them in whom radiographs were available at the time of diagnosis, showed extremely decreased bone density. Osteoporosis has been not previously described in patients with ACTH insensitivity. We assumed that it is at least partly result of decreased adrenal androgen production established in our patients. HLA typing was performed. This syndrome is not linked to HLA complex, or associated with some specific HLA antigens.

osteoporosis; ACTH insensitivity; nervous system disorders; children

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