engleski

Adrenocorticotropic hormone insensitivity associated with autonomic nervous system disorders

Five children with adrenocorticotropic hormone (ACTH) insensitivity associated with autonomic nervous system disorders are described. A t the time of diagnosis, four of them had osteoporosis. The fifth p a t i e n t died and skeletal roentgenograms were n o t done. Osteoporosis was subsequently discovered in one of our previously rep o r t e d patients with ACTH insensitivity. We assume that osteoporosis is, at least partly, the result of decreased adrenal androgen production. Human leucocyte antigen typing failed to establish any linkage.

ACTH insensitivity ; adrenal insufficiency ; autonomic nervous system disorders ; osteoporosis ; HLA typing

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