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Pregled bibliografske jedinice broj: 728246

A girl with isolated diffuse mesangial sclerosis and WT1 mutation


Vrljicak, Kristina; Batinic, Danica; Milosevic, Danko; Coric, Marijana; Stancin, Liljana; Kniewald, Hrvoje; Slavicek, Jasna; Lemac, Maja; Hodzic, Sonja; Hildebrandt, Friedhelm
A girl with isolated diffuse mesangial sclerosis and WT1 mutation // Meeting abstract / Pediatric nephrology (ur.).
New York: Springer Verlag, 2012. str. 1716-1716 (poster, međunarodna recenzija, sažetak, stručni)


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Naslov
A girl with isolated diffuse mesangial sclerosis and WT1 mutation

Autori
Vrljicak, Kristina ; Batinic, Danica ; Milosevic, Danko ; Coric, Marijana ; Stancin, Liljana ; Kniewald, Hrvoje ; Slavicek, Jasna ; Lemac, Maja ; Hodzic, Sonja ; Hildebrandt, Friedhelm

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Meeting abstract / Pediatric nephrology - New York : Springer Verlag, 2012, 1716-1716

Skup
Pediatrics, Urology & Nephrology

Mjesto i datum
Krakov, Poljska, 14-17.09.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
diffuse mesangial sclerosis; WT1 mutation

Sažetak
Introduction: Isolated diffuse mesangial sclerosis (IDMS) is a histologically distinct variant of nephrotic syndrome with early onset and progression to end-stage kidney disease. Mutations in PLCE1, WT1 and LAMB2 genes may cause IDMS. Carriers of a WT1 mutation are at risk for the development of Wilm’s tumor and gonadoblastoma.Material and methods: Our patient is a female, born from a normal pregnancy, healthy ; BW 3900 g. Family history is unremarkable. At the age of 4 months proteinuria was detected during a febrile respiratory infection. Methods: laboratory analysis, renal biopsy, ultrasound, abdominal MRI, genetic analysis.Results: When she was 8 months old, she was admitted to our Department and we found proteinuria (1.4 g/dU), hypogammaglobulinemia (IgG 0.83 g/l) and a patent foramen ovale. Ultrasound showed hyperechoic kidneys of normal size Renal biopsy revealed diffuse mesangial sclerosis and multifocal nephroblastic proliferative lesions. Her karyotype is 46, XX, 1qh + (population variant). She has a WT1 mutation (Ex9: c.1165 C > T), heterozygous. In the follow up period she received intravenous immunoglobulin and underwent ultrasound screening for tumors monthly. At the age of 3 years and 3 months she is a well developed girl, with normal blood pressure and without edema. Laboratory findings show non-selective glomerular proteinuria (2.47 g/dU), hypoproteinemia (49 g/l), hypogammaglobulinemia (1.72 g/l) and hypercholesterolemia (9.1 mmol/l). Other findings are within reference ranges. There are no detectable expansive lesions at abdominal MRI and ultrasound examination.Conclusions: Our patient has a favorable course of the disease so far. She has a persistent hypogammaglobulinemia in spite of substitution. Patients with IDMS do not respond to corticosteroid and immunosuppressive therapy. It was reported that one child with PLCE1 mutation responded to cyclosporine therapy. So, patients with IDMS should be tested for mutations to find those who might benefit f

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb


Citiraj ovu publikaciju:

Vrljicak, Kristina; Batinic, Danica; Milosevic, Danko; Coric, Marijana; Stancin, Liljana; Kniewald, Hrvoje; Slavicek, Jasna; Lemac, Maja; Hodzic, Sonja; Hildebrandt, Friedhelm
A girl with isolated diffuse mesangial sclerosis and WT1 mutation // Meeting abstract / Pediatric nephrology (ur.).
New York: Springer Verlag, 2012. str. 1716-1716 (poster, međunarodna recenzija, sažetak, stručni)
Vrljicak, K., Batinic, D., Milosevic, D., Coric, M., Stancin, L., Kniewald, H., Slavicek, J., Lemac, M., Hodzic, S. & Hildebrandt, F. (2012) A girl with isolated diffuse mesangial sclerosis and WT1 mutation. U: Pediatric nephrology (ur.)Meeting abstract.
@article{article, year = {2012}, pages = {1716-1716}, keywords = {diffuse mesangial sclerosis, WT1 mutation}, title = {A girl with isolated diffuse mesangial sclerosis and WT1 mutation}, keyword = {diffuse mesangial sclerosis, WT1 mutation}, publisher = {Springer Verlag}, publisherplace = {Krakov, Poljska} }
@article{article, year = {2012}, pages = {1716-1716}, keywords = {diffuse mesangial sclerosis, WT1 mutation}, title = {A girl with isolated diffuse mesangial sclerosis and WT1 mutation}, keyword = {diffuse mesangial sclerosis, WT1 mutation}, publisher = {Springer Verlag}, publisherplace = {Krakov, Poljska} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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