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A genome-wide association study of anorexia nervosa


Boraska, Vesna; Franklin, C.S.; Floyd, J.A.; Thornton, L.M.; Huckins, L.M.; Southam, L.; Rayner, N.W.; Tachmazidou, I.; Klump, K.L.; Treasure, J. et al.
A genome-wide association study of anorexia nervosa // Molecular psychiatry, 19 (2014), 10; 1085-1094 doi:10.1038/mp.2013.187 (međunarodna recenzija, članak, znanstveni)


Naslov
A genome-wide association study of anorexia nervosa

Autori
Boraska, Vesna ; Franklin, C.S. ; Floyd, J.A. ; Thornton, L.M. ; Huckins, L.M. ; Southam, L. ; Rayner, N.W. ; Tachmazidou, I. ; Klump, K.L. ; Treasure, J. ; Lewis, C.M. ; Schmidt, U. ; Tozzi, F. ; Kiezebrink, K. ; Hebebrand, J. ; Gorwood, P. ; Adan, R.A. ; Kas, M.J. ; Favaro, A. ; Santonastaso, P. ; Fernández-Aranda, F. ; Gratacos, M. ; Rybakowski, F. ; Dmitrzak-Weglarz, M. ; Kaprio, J. ; Keski-Rahkonen, A. ; Raevuori, A. ; Van Furth, E.F. ; Slof-Op 't Landt, M.C. ; Hudson, J.I. ; Reichborn-Kjennerud, T. ; Knudsen, G.P. ; Monteleone, P. ; Kaplan, A.S. ; Karwautz, A. ; Hakonarson, H. ; Berrettini, W.H. ; Guo, Y. ; Li, D. ; Schork, N.J. ; Komaki, G. ; Ando, T. ; Inoko, H. ; Esko, T. ; Fischer, K. ; Männik, K. ; Metspalu, A. ; Baker, J.H. ; Cone, R.D. ; Dackor, J. ; DeSocio, J.E. ; Hilliard, C.E. ; O'Toole, J.K. ; Pantel, J. ; Szatkiewicz, J.P. ; Taico, C. ; Zerwas, S. ; Trace, S.E. ; Davis, O.S. ; Helder, S. ; Bühren, K. ; Burghardt, R. ; de Zwaan, M. ; Egberts, K. ; Ehrlich, S. ; Herpertz-Dahlmann, B. ; Herzog, W. ; Imgart, H. ; Scherag, A. ; Scherag, S. ; Zipfel, S. ; Boni, C. ; Ramoz, N. ; Versini, A. ; Brandys, M.K. ; Danner, U.N. ; de Kovel, C. ; Hendriks, J. ; Koeleman, B.P. ; Ophoff, R.A. ; Strengman, E. ; van Elburg, A.A. ; Bruson, A. ; Clementi, M. ; Degortes, D. ; Forzan, M. ; Tenconi, E. ; Docampo, E. ; Escaramís, G.. ; Jiménez-Murcia, S ; Lissowska, J. ; Rajewski, A. ; Szeszenia-Dabrowska, N. ; Slopien, A. ; Hauser, J. ; Karhunen, L. ; Meulenbelt, I. ; Slagboom, P.E. ; Tortorella, A. ; Maj, M. ; Dedoussis, G. ; Dikeos, D. ; Gonidakis, F. ; Tziouvas, K. ; Tsitsika, A. ; Papezova, H. ; Slachtova, L. ; Martaskova, D. ; Kennedy, J.L. ; Levitan, R.D. ; Yilmaz, Z. ; Huemer, J. ; Koubek, D. ; Merl, E. ; Wagner, G. ; Lichtenstein, P. ; Breen, G. ; Cohen-Woods, S. ; Farmer, A. ; McGuffin, P. ; Cichon, S. ; Giegling, I. ; Herms, S. ; Rujescu, D. ; Schreiber, S. ; Wichmann, H.E. ; Dina, C. ; Sladek, R. ; Gambaro, G. ; Soranzo, N. ; Julia, A. ; Marsal, S ; Rabionet, R ; Gaborieau, V ; Dick, D.M. ; Palotie, A. ; Ripatti, S. ; Widén, E. ; Andreassen, OA ; Espeseth, T ; Lundervold, A ; Reinvang, I. ; Steen, V.M. ; Le Hellard, S. ; Mattingsdal, M. ; Ntalla, I. ; Bencko, V. ; Foretova, L. ; Janout, V. ; Navratilova, M. ; Gallinger, S. ; Pinto, D. ; Scherer, S.W. ; Aschauer, H. ; Carlberg, L. ; Schosser, A. ; Alfredsson, L. ; Ding, B. ; Klareskog, L. ; Padyukov, L. ; Courtet, P. ; Guillaume, S. ; Jaussent, I. ; Finan, C. ; Kalsi, G. ; Roberts, M. ; Logan, D.W. ; Peltonen, L. ; Ritchie, G.R. ; Barrett, J.C. ; Wellcome Trust Case Control Consortium 3 ; Estivill, X ; Hinney, A ; Sullivan, PF ; Collier, DA ; Zeggini, E ; Bulik, CM

Izvornik
Molecular psychiatry (1359-4184) 19 (2014), 10; 1085-1094

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Anorexia nervosa; body mass index; eating disorders; genome-wide association study; GWAS; metabolic

Sažetak
Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results. We performed a GWAS in 2907 cases with AN from 14 countries (15 sites) and 14 860 ancestrally matched controls as part of the Genetic Consortium for AN (GCAN) and the Wellcome Trust Case Control Consortium 3 (WTCCC3). Individual association analyses were conducted in each stratum and meta-analyzed across all 15 discovery data sets. Seventy-six (72 independent) single nucleotide polymorphisms were taken forward for in silico (two data sets) or de novo (13 data sets) replication genotyping in 2677 independent AN cases and 8629 European ancestry controls along with 458 AN cases and 421 controls from Japan. The final global meta-analysis across discovery and replication data sets comprised 5551 AN cases and 21 080 controls. AN subtype analyses (1606 AN restricting ; 1445 AN binge–purge) were performed. No findings reached genome-wide significance. Two intronic variants were suggestively associated: rs9839776 (P = 3.01 × 10− 7) in SOX2OT and rs17030795 (P = 5.84 × 10− 6) in PPP3CA. Two additional signals were specific to Europeans: rs1523921 (P = 5.76 × 10−6) between CUL3 and FAM124B and rs1886797 (P = 8.05 × 10−6) near SPATA13. Comparing discovery with replication results, 76% of the effects were in the same direction, an observation highly unlikely to be due to chance (P=4×10− 6), strongly suggesting that true findings exist but our sample, the largest yet reported, was underpowered for their detection. The accrual of large genotyped AN case-control samples should be an immediate priority for the field.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
HRZZ-PD-02.03/68 - Analiza i interpretacija cjelogenomskih studija povezanosti: primjena u projektu 10,001 Dalmatinac (Vesna Boraska, )

Ustanove
Medicinski fakultet, Split

Autor s matičnim brojem:
Vesna Boraska, (276771)

Citiraj ovu publikaciju

Boraska, Vesna; Franklin, C.S.; Floyd, J.A.; Thornton, L.M.; Huckins, L.M.; Southam, L.; Rayner, N.W.; Tachmazidou, I.; Klump, K.L.; Treasure, J. et al.
A genome-wide association study of anorexia nervosa // Molecular psychiatry, 19 (2014), 10; 1085-1094 doi:10.1038/mp.2013.187 (međunarodna recenzija, članak, znanstveni)
Boraska, V., Franklin, C., Floyd, J., Thornton, L., Huckins, L., Southam, L., Rayner, N., Tachmazidou, I., Klump, K. & Treasure, J. (2014) A genome-wide association study of anorexia nervosa. Molecular psychiatry, 19 (10), 1085-1094 doi:10.1038/mp.2013.187.
@article{article, year = {2014}, pages = {1085-1094}, DOI = {10.1038/mp.2013.187}, keywords = {anorexia nervosa, body mass index, eating disorders, genome-wide association study, GWAS, metabolic}, journal = {Molecular psychiatry}, doi = {10.1038/mp.2013.187}, volume = {19}, number = {10}, issn = {1359-4184}, title = {A genome-wide association study of anorexia nervosa}, keyword = {anorexia nervosa, body mass index, eating disorders, genome-wide association study, GWAS, metabolic} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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