engleski

Pro-atrial natriuretic peptide hormone from right atria is correlated with cardiac depression in septic patients

N-terminal pro-atrial natriuretic peptide (ProANP (I-98))has been extensively investigated in patients wirh chronic heart failure and ischemic heart disease. It is found to be a better marker of cardiac dysfunction than atrial natriuretic peptide (ANP). The possible involvement of ProANP(I-98) in cardiac depression caused by sepsis has not been studied yet. Therefore, we analyzed atrial plasma concentration of ProANP(I-98)in 17 septic patients with hemodynamic variables measured or calculated using pulmonary artery catheter. The results of altogether measurements show a significant negative correlation of ProANP(I-98)and cardiac index (p<0.024), oxygen delivery (p<0.03) and oxygen consumption (p<0.03). There is also a positive correlation with pulmonary vascular resistance (p<0.03). ProANP(I-98) is significantly higher in patients who developed acute respiratory distress syndrome (ARDS) (p<0.001). This study implies that proANP(I-98) is a possible novel hormone marker od cardiac depression caused by sepsis that could be used for prediction od ARDS.

ProANP (I-98) ; plasma ; intensive care ; sepsis ; cardiac depression ; ARDS

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