engleski

Second Primary Malignant Tumors in Patients with Primary Colorectal Adenocarcinoma

The aim of the study was to determine the frequency and types of second primary malignancy in patients with primary colorectal adenocarcinoma. Atotal of 2035 (1200 male and 835 female) patients with colorectal carcinoma were analyzed. Data were obtained from the computer based colorectal cancer registry at Ljudevit Jurak University Department of Pathology for the 1995- 2003 period. The database contains data on each patient including pathohistologic diagnosis. The following parameters were analyzed: sex and age distribution, and localization of second primary malignant tumors in patients with primary colorectal carcinoma.There were 107/2035 (5, 3%) patients with second primary malignancy, 59 (3%) men and 48 (2, 3%) women. Second primary malignancies in descending order of frequency were: stomach (16, 5%), prostate (13, 9%), skin (13%), urinary bladder (11, 3%), and kidney cancer (6, 9%). 91, 5% patients had only one second malignancy, whereas 8, 5% patients had more than one second malignancy. It is concluded that the histopathologic type and location of second primary malignancy can be of great importance for patients, their physicians and pathologist.In this series the frequency of secondary malignancies was much higher than expected, reaching up to 5% of patients.Had we excluded skin cancers from the analysis, the frequency of second primary malignancies would probably be lower, but data should be checked at the National Cancer Registry.

colorectal adenocarcinoma ; second primary malignancy ; colorectal cancer registry

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