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Pregled bibliografske jedinice broj: 726678

Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha(2)beta(1)integrin


Bix, Gregory; ...; Campbell, Shelly; Zutter, Mary M.; Santoro, Samuel A.; Kim, Jiyeun K.; Höök, Magnus; Reed, Charles C.; Iozzo, Renato V.
Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha(2)beta(1)integrin // The Journal of cell biology, 166 (2004), 1; 97-109 doi:10.1083/jcb.200401150 (međunarodna recenzija, članak, znanstveni)


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Naslov
Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha(2)beta(1)integrin

Autori
Bix, Gregory ; ... ; Campbell, Shelly ; Zutter, Mary M. ; Santoro, Samuel A. ; Kim, Jiyeun K. ; Höök, Magnus ; Reed, Charles C. ; Iozzo, Renato V.

Izvornik
The Journal of cell biology (0021-9525) 166 (2004), 1; 97-109

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Actins/metabolism; Cytoskeleton/metabolism; Endothelium; Vascular/cytology; Protein-Tyrosine Kinases/metabolism

Sažetak
Endorepellin, the COOH-terminal domain of the heparan sulfate proteoglycan perlecan, inhibits several aspects of angiogenesis. We provide evidence for a novel biological axis that links a soluble fragment of perlecan protein core to the major cell surface receptor for collagen alpha(2)beta(1)integrin, and provide an initial investigation of the intracellular signaling events that lead to endorepellin antiangiogenic activity. The interaction between endorepellin and integrin triggers a unique signaling pathway that causes an increase in the second messenger cAMP ; activation of two proximal kinases, protein kinase A and focal adhesion kinase ; transient activation of p38 mitogen-activated protein kinase and heat shock protein 27, followed by a rapid down-regulation of the latter two proteins ; and ultimately disassembly of actin stress fibers and focal adhesions. The end result is a profound block of endothelial cell migration and angiogenesis. Because perlecan is present in both endothelial and smooth muscle cell basement membranes, proteolytic activity during the initial stages of angiogenesis could liberate antiangiogenic fragments from blood vessels’ walls, including endorepellin.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

Napomena
Shelly Pranić je rođena Shelly Campbell



POVEZANOST RADA


Profili:

Avatar Url Shelly Pranić (autor)

Citiraj ovu publikaciju

Bix, Gregory; ...; Campbell, Shelly; Zutter, Mary M.; Santoro, Samuel A.; Kim, Jiyeun K.; Höök, Magnus; Reed, Charles C.; Iozzo, Renato V.
Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha(2)beta(1)integrin // The Journal of cell biology, 166 (2004), 1; 97-109 doi:10.1083/jcb.200401150 (međunarodna recenzija, članak, znanstveni)
Bix, G., ..., Campbell, S., Zutter, M., Santoro, S., Kim, J., Höök, M., Reed, C. & Iozzo, R. (2004) Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha(2)beta(1)integrin. The Journal of cell biology, 166 (1), 97-109 doi:10.1083/jcb.200401150.
@article{article, year = {2004}, pages = {97-109}, DOI = {10.1083/jcb.200401150}, keywords = {Actins/metabolism, Cytoskeleton/metabolism, Endothelium, Vascular/cytology, Protein-Tyrosine Kinases/metabolism}, journal = {The Journal of cell biology}, doi = {10.1083/jcb.200401150}, volume = {166}, number = {1}, issn = {0021-9525}, title = {Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha(2)beta(1)integrin}, keyword = {Actins/metabolism, Cytoskeleton/metabolism, Endothelium, Vascular/cytology, Protein-Tyrosine Kinases/metabolism} }
@article{article, year = {2004}, pages = {97-109}, DOI = {10.1083/jcb.200401150}, keywords = {Actins/metabolism, Cytoskeleton/metabolism, Endothelium, Vascular/cytology, Protein-Tyrosine Kinases/metabolism}, journal = {The Journal of cell biology}, doi = {10.1083/jcb.200401150}, volume = {166}, number = {1}, issn = {0021-9525}, title = {Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha(2)beta(1)integrin}, keyword = {Actins/metabolism, Cytoskeleton/metabolism, Endothelium, Vascular/cytology, Protein-Tyrosine Kinases/metabolism} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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