Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 726584

Blood lactate levels in patients receiving first- or second- generation antipsychotics


Glavina, Trpimir; Mrass, Damir; Dodig, Tajana; Glavina, Gordana; Pranić, Shelly; Uglešić, Boran
Blood lactate levels in patients receiving first- or second- generation antipsychotics // Croatian medical journal, 52 (2011), 1; 41-47 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 726584 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Blood lactate levels in patients receiving first- or second- generation antipsychotics

Autori
Glavina, Trpimir ; Mrass, Damir ; Dodig, Tajana ; Glavina, Gordana ; Pranić, Shelly ; Uglešić, Boran

Izvornik
Croatian medical journal (0353-9504) 52 (2011), 1; 41-47

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
antipsychotics; lactates; adverse effects

Sažetak
Aim: To compare the blood lactate levels between patients with psychotic disorder receiving first- and those receiving second-generation antipsychotics. Methods: The study was conducted at the psychiatric inpatient and outpatient clinics of the Split Clinical Hospital from June 6, 2008 to October 10, 2009. Sixty patients with psychotic disorder who were assigned to 6-month treatment were divided in two groups: 30 received haloperidol (first generation antipsychotic) and 30 received olanzapine (second generation antipsychotic). Blood lactate levels, other metabolic parameters, and scores on the extrapyramidal symptom rating scale were assessed. Results: Patients receiving haloperidol had significantly higher blood lactate levels than patients receiving olanzapine (P < 0.001). They also more frequently had Parkinsonism, which was significantly correlated with both haloperidol treatment at 1 month (P < 0.001) and 6 months (P = 0.016) and olanzapine treatment at baseline (P = 0.016), 3 months (P = 0.019), and 6 months (P = 0.021). Also, patients receiving haloperidol had significant correlation between blood lactate and dystonia at 1 month (P < 0.001) and 6 months (P = 0.012) and tardive dyskinesia at 1 month (P = 0.032). There was a significant difference between the treatment groups in lactate levels at all points from baseline to month 6 (P < 0.001). Conclusion: It is important to be aware of the potential effect of haloperidol treatment on increase in blood lactate levels and occurrence of extrapyramidal side effects. Therefore, alternative antipsychotics should be prescribed with lower risk of adverse side effects.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Klinika za psihijatriju Vrapče,
KBC Split,
Medicinski fakultet, Split

Profili:

Avatar Url Shelly Pranić (autor)

Avatar Url Trpimir Glavina (autor)

Avatar Url Boran Uglešić (autor)

Citiraj ovu publikaciju

Glavina, Trpimir; Mrass, Damir; Dodig, Tajana; Glavina, Gordana; Pranić, Shelly; Uglešić, Boran
Blood lactate levels in patients receiving first- or second- generation antipsychotics // Croatian medical journal, 52 (2011), 1; 41-47 (međunarodna recenzija, članak, znanstveni)
Glavina, T., Mrass, D., Dodig, T., Glavina, G., Pranić, S. & Uglešić, B. (2011) Blood lactate levels in patients receiving first- or second- generation antipsychotics. Croatian medical journal, 52 (1), 41-47.
@article{article, year = {2011}, pages = {41-47}, keywords = {antipsychotics, lactates, adverse effects}, journal = {Croatian medical journal}, volume = {52}, number = {1}, issn = {0353-9504}, title = {Blood lactate levels in patients receiving first- or second- generation antipsychotics}, keyword = {antipsychotics, lactates, adverse effects} }
@article{article, year = {2011}, pages = {41-47}, keywords = {antipsychotics, lactates, adverse effects}, journal = {Croatian medical journal}, volume = {52}, number = {1}, issn = {0353-9504}, title = {Blood lactate levels in patients receiving first- or second- generation antipsychotics}, keyword = {antipsychotics, lactates, adverse effects} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • BIOSIS Previews (Biological Abstracts)
  • MEDLINE
  • ISI Alerting Service
  • Scopus





Contrast
Increase Font
Decrease Font
Dyslexic Font