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Pregled bibliografske jedinice broj: 726439

Glycosylation pattern and axin expression in normal and IUGR placentae


Vukasović, Andreja; Grbeša, Đurđica; Nikuševa-Martić, Tamara; Kušec, Vesna; Mišković, Berivoj; Šerman, Alan; Soken, Nikolina; Šerman, Ljiljana
Glycosylation pattern and axin expression in normal and IUGR placentae // Journal of maternal-fetal & neonatal medicine, 18 (2014), 5; 558-563 doi:10.3109/14767058.2014.926326 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 726439 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Glycosylation pattern and axin expression in normal and IUGR placentae

Autori
Vukasović, Andreja ; Grbeša, Đurđica ; Nikuševa-Martić, Tamara ; Kušec, Vesna ; Mišković, Berivoj ; Šerman, Alan ; Soken, Nikolina ; Šerman, Ljiljana

Izvornik
Journal of maternal-fetal & neonatal medicine (1476-7058) 18 (2014), 5; 558-563

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
glycoproteins; human placenta; intrauterine growth restriction; lectins; Wnt signaling pathway

Sažetak
Objective: The aim of this study was to investigate the protein glycosylation pattern and AXIN1 protein expression in human placentae of normal pregnancies and compare them with placentae of pregnancies complicated with intrauterine growth restriction (IUGR). Methods:A total of 38 placentae (17 placentae of IUGR fetuses from singleton pregnancies) were collected from the Clinical Hospital Sveti Duh, Department of Gynecology and Obstetrics, Zagreb, Croatia. Gestational age was determined according to the last menstrual period (LMP) and by ultrasound measurements. Expression of glycoproteins was measured by Western blotting with SNA, UE-I, PHA-E and DBA lectins as probes whereas expression of AXIN1 was determined by immunohistochemistry. Results:Comparison of detected sugars revealed differences in protein glycosylation between normal and IUGR placentae.Higher expression of AXIN1 protein located mostlyin the cytoplasm of syncytiotrophoblast and to a lesser extent in its nuclei was found in IUGR placentae. Conclusion: Results of our study suggest that changes in glycoprotein content may contribute to restricted placenta growth and development. Higher expression of AXIN1 protein in IUGR placenta indicates a role of Wnt/beta-catenin signaling pathway in pathology of placental development

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
108-1080399-0383 - Muški i ženski spolni sustav: razvoj, normalna histofiziologija i neplodnost (Ježek, Davor, MZOS ) ( POIROT)
214-1080229-0163 - Zajednička molekularna osnova etiopatogeneza koštanih poremećaja u ljudi (Kušec, Vesna, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb,
Klinička bolnica "Sveti Duh",
Klinički bolnički centar Zagreb

Poveznice na cjeloviti tekst rada:

doi www.tandfonline.com

Citiraj ovu publikaciju:

Vukasović, Andreja; Grbeša, Đurđica; Nikuševa-Martić, Tamara; Kušec, Vesna; Mišković, Berivoj; Šerman, Alan; Soken, Nikolina; Šerman, Ljiljana
Glycosylation pattern and axin expression in normal and IUGR placentae // Journal of maternal-fetal & neonatal medicine, 18 (2014), 5; 558-563 doi:10.3109/14767058.2014.926326 (međunarodna recenzija, članak, znanstveni)
Vukasović, A., Grbeša, Đ., Nikuševa-Martić, T., Kušec, V., Mišković, B., Šerman, A., Soken, N. & Šerman, L. (2014) Glycosylation pattern and axin expression in normal and IUGR placentae. Journal of maternal-fetal & neonatal medicine, 18 (5), 558-563 doi:10.3109/14767058.2014.926326.
@article{article, author = {Vukasovi\'{c}, Andreja and Grbe\v{s}a, \DJur\djica and Niku\v{s}eva-Marti\'{c}, Tamara and Ku\v{s}ec, Vesna and Mi\v{s}kovi\'{c}, Berivoj and \v{S}erman, Alan and Soken, Nikolina and \v{S}erman, Ljiljana}, year = {2014}, pages = {558-563}, DOI = {10.3109/14767058.2014.926326}, keywords = {glycoproteins, human placenta, intrauterine growth restriction, lectins, Wnt signaling pathway}, journal = {Journal of maternal-fetal and neonatal medicine}, doi = {10.3109/14767058.2014.926326}, volume = {18}, number = {5}, issn = {1476-7058}, title = {Glycosylation pattern and axin expression in normal and IUGR placentae}, keyword = {glycoproteins, human placenta, intrauterine growth restriction, lectins, Wnt signaling pathway} }
@article{article, author = {Vukasovi\'{c}, Andreja and Grbe\v{s}a, \DJur\djica and Niku\v{s}eva-Marti\'{c}, Tamara and Ku\v{s}ec, Vesna and Mi\v{s}kovi\'{c}, Berivoj and \v{S}erman, Alan and Soken, Nikolina and \v{S}erman, Ljiljana}, year = {2014}, pages = {558-563}, DOI = {10.3109/14767058.2014.926326}, keywords = {glycoproteins, human placenta, intrauterine growth restriction, lectins, Wnt signaling pathway}, journal = {Journal of maternal-fetal and neonatal medicine}, doi = {10.3109/14767058.2014.926326}, volume = {18}, number = {5}, issn = {1476-7058}, title = {Glycosylation pattern and axin expression in normal and IUGR placentae}, keyword = {glycoproteins, human placenta, intrauterine growth restriction, lectins, Wnt signaling pathway} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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