engleski

DETECTING SODIUM SENSITIVITY RISK FROM AMBULATORY BLOOD PRESSURE MONITORING. DATA FROM THE CROATIAN REGISTRY ON ABPM (HRKMAT)

Introduction: High daily sodium intake is associated with various deteriorating effects on cardiovascular(CV) system. Sodium sensitivity(SS) of blood pressure(BP) increases CV and overall mortality. Recently, estimation of SS risk from the ABPM data in regular every- day conditions and habitual diet was proposed. Our aim was to analyse prevalence and characteristics of subjects with high SS risk in cohort of subjects from our ABPM database. Design and Methods: In this retrospective study we analysed data on 485 subjects(64.9% men). ABPM was performed on regular working day using SpaceLab device. Subjects were divided into 3 classes of SS: low risk if dippers and a 24-h heart rate(HR) ≤70 bpm (LSS) ; high risk if non-dippers and a 24-h HR of >70 bpm (HSS) ; intermediate risk with the remaining combinations(dippers with HR>70 bpm or non- dippers with HR ≤ 70 bpm). Patients were classified as “dippers” when nocturnal mean arterial pressure fall was >10% and „non- dippers“otherwise. Results: Prevalence of HSS subjects was 22.6% with no gender difference. We failed to observe an increase in SS by ageing. No difference in age (48.5 (20-87) vs.53(19-88) ; p>0.05) and eGFR (92.9± 9.4 vs.95.9±12 ; p>0.05) was observed between HSS and LSS subjects. HSS subjects had lower BMI (25.9(21.8-29.4) vs.27.5(24.8- 29.9) ; p=0.03) and waist circumference (89.5(78- 104) vs.92(83-104) ; p=0.031)than LSS. Interestingly we failed to determine difference in systolic BP (127.5(120- 139)vs. 126(119- 133) ; p=0, 3171) and pulse pressure (52(46-59) vs.53(47- 58) ; p=0.485) values between HSS and LSS.However, there were more masked hypertension in HSS, and more white coat hypertension in LSS groups (χ2 =13.55 ; p<0.001). Conclusion: Prevalence of HSS in this study was lower than expected probably our cohort was younger than others(33.8% were younger than 40 yr). HSS subjects did not differ in age, kidney function and indices of arterial stiffness from those with LSS risk. Interestingly, masked hypertension was more prevalent in HSS and white coat hypertension in LSS subjects. Proposed method for SS estimation could be useful in everyday practice particularly when more specific cut-off values would be determined.Retrospective analyses of existing database could provide interesting and valuable information. However, in such analyses one should take into account characteristics of group and of each subject.

sol osjetljivost; KMAT; HRKMAT

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