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izvor podataka: crosbi

Volumetric analysis of cerebrospinal fluid and brain parenchyma in a patient with hydranencephaly and macrocephaly : case report (CROSBI ID 210795)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Radoš, Milan ; Klarica, Marjan ; Mučić-Pucić, Branka ; Nikić, Ines ; Raguž, Marina ; Galkowski, Valentina ; Mandić, Dora ; Orešković, Darko Volumetric analysis of cerebrospinal fluid and brain parenchyma in a patient with hydranencephaly and macrocephaly : case report // Croatian medical journal, 55 (2014), 4; 388-393. doi: 10.3325/cmj.2014.55.388

Podaci o odgovornosti

Radoš, Milan ; Klarica, Marjan ; Mučić-Pucić, Branka ; Nikić, Ines ; Raguž, Marina ; Galkowski, Valentina ; Mandić, Dora ; Orešković, Darko

engleski

Volumetric analysis of cerebrospinal fluid and brain parenchyma in a patient with hydranencephaly and macrocephaly : case report

The aim of this study was to perform for the first time the intracranial volumetric analysis of cerebrospinal fluid (CSF) and brain parenchyma in the supratentorial and infratentorial space in a 30-year-old female patient with hydranencephaly and macrocephaly. A head scan performed using a 3T magnetic resonance was followed by manual segmentation of the brain parenchyma and CSF on T2 coronal brain sections. The volume of CSF and brain parenchyma was measured separately for the supratentorial and infratentorial space. The total volume of the intracranial space was 3645.5 cm3. In the supratentorial space, the volume of CSF was 3375.2 cm3 and the volume of brain parenchyma was 80.3 cm3. In the infratentorial space, the volume of CSF was 101.3 cm3 and the volume of the brain parenchyma was 88.7 cm3. In the supratentorial space, there was severe malacia of almost all brain parenchyma with no visible remnants of the choroid plexuses. Infratentorial structures of the brainstem and cerebellum were hypoplastic but completely developed. Since our patient had no choroid plexuses in the supratentorial space and no obstruction between dural sinuses and CSF, development of hydrocephalus and macrocephaly cannot be explained by the classic hypothesis of CSF physiology with secretion, unidirectional circulation, and absorption as its basic postulates. However, the origin and turnover of the enormous amount of intracranial CSF volume, at least 10-fold larger than normal, and the mechanisms of macroencephaly development could be elucidated by the new hypothesis of CSF physiology recently published by our research team.

volumetric analysis ; hydranencephaly ; macrocephaly ; cerebrospinal fluid

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Podaci o izdanju

55 (4)

2014.

388-393

objavljeno

0353-9504

10.3325/cmj.2014.55.388

Povezanost rada

Temeljne medicinske znanosti

Poveznice
Indeksiranost