The association of inflammatory markers with cerebral vasoreactivity and carotid atherosclerosis in transient ischaemic attack

Martinić Popović, Irena; Šimundić, Ana-Maria; Dukić, Lora; Lovrenčić-Huzjan, Arijana; Popović, Alek; Šerić, Vesna; Bašić Kes, Vanja; Demarin, Vida

doi:10.1016/j.clinbiochem.2014.07.010

Pregled bibliografske jedinice broj: 725005

The association of inflammatory markers with cerebral vasoreactivity and carotid atherosclerosis in transient ischaemic attack

Martinić Popović, Irena; Šimundić, Ana-Maria; Dukić, Lora; Lovrenčić-Huzjan, Arijana; Popović, Alek; Šerić, Vesna; Bašić Kes, Vanja; Demarin, Vida

The association of inflammatory markers with cerebral vasoreactivity and carotid atherosclerosis in transient ischaemic attack // Clinical biochemistry, 47 (2014), 16/17; 182-186 doi:10.1016/j.clinbiochem.2014.07.010 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 725005 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The association of inflammatory markers with cerebral vasoreactivity and carotid atherosclerosis in transient ischaemic attack

Autori
Martinić Popović, Irena ; Šimundić, Ana-Maria ; Dukić, Lora ; Lovrenčić-Huzjan, Arijana ; Popović, Alek ; Šerić, Vesna ; Bašić Kes, Vanja ; Demarin, Vida

Izvornik
Clinical biochemistry (0009-9120) 47 (2014), 16/17; 182-186

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Transient ischaemic attack ; Inflammation ; IL-6 ; CRP ; ICAM-1

Sažetak
Inflammatory mediators have an important role in the pathogenesis of stroke. Increased activity of inflammatory mediators initiates the development of atherosclerosis independently of other risk factors, thus compromising brain microcirculation and causing transient ischaemic attack (TIA). The aim of our study was to evaluate the relationship between serumlevel of cellular adhesion molecules (ICAM-1), interleukin-6 (IL-6) and C-reactive protein (CRP) with carotid intima–media thickness (IMT) and breath-holding index (BHI) in subjects with transient ischaemic attack. We also aimed to assess the difference of those markers between TIA patients and disease-free control individuals. The study included 45 TIA patients and 36 disease-free controls matched for age, gender and vascular risk profile. The degree of carotid atherosclerosis was assessed by colour Dopplerwith measurements of carotid IMT. Transcranial Doppler (TCD) ultrasoundwas performed in order to assess BHI. IMT, TCD, BHI and serum concentrations of ICAM-1, IL-6, and CRP were measured for all study subjects. Inflammatory markers IL-6, ICAM-1 and CRP were significantly higher in TIA patients than in disease-free controls (P b 0.001, P = 0.026, P b 0.001, respectively). TIA patients had significantly lower values of BHI and higher IMT relative to disease-free control individuals (P b 0.001). TIA is associated with higher ICAM-1, IL-6 and CRP, pointing to the marked inflammatory response to cerebral ischaemia. Inflammatory markers are associated with higher IMT and lower BHI, indicating the insufficient cerebral perfusion due to the underlying atherosclerotic disease. Our findings highlight the key significance of inflammation in the early response to ischaemia during the transitory ischaemic episode.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA

Projekti:
022-1340036-2083 - Frontotemporalne demencije (Liščić, Rajka, MZOS ) ( CroRIS)
134-0000000-3381 - Promjene bubrežne arterije u bolesnika s karcinomom bubrega (Čupić, Hrvoje, MZOS ) ( CroRIS)
134-1340036-0033 - Uloga genetskih markera u razvoju cerebralne aterosklerotske bolesti (Demarin, Vida, MZOS ) ( CroRIS)
134-1340036-0034 - Funkcijska dijagnostika moždane cirkulacije (Lovrenčić-Huzjan, Arijana, MZOS ) ( CroRIS)
134-1340036-0035 - Uloga vaskularnih čimbenika rizika u patogenezi Alzheimerove bolesti (Trkanjec, Zlatko, MZOS ) ( CroRIS)
134-1340227-0200 - Upala i udio farmakogenetike u razvoju i ishodu akutnih i kroničnih bolesti (Šimundić, Ana-Maria, MZOS ) ( CroRIS)
143-1080002-0050 - Dijagnostika i liječenje bolesnika sa sindromom prostatitisa (Škerk, Višnja, MZOS ) ( CroRIS)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
KBC "Sestre Milosrdnice",
Klinika za infektivne bolesti "Dr Fran Mihaljević"

Profili:

Ana-Maria Šimundić (autor)