engleski

Serum Omentin-1 Level as a Possible Risk Factor of Mortality in Diabetic Patients on Haemodialysis

Background: The main cause of mortality in haemodialysis patients are cardiovascular diseases (CVD). It's important to identify and prevent cardiovascular risk factors in end stage renal disease (ESRD) patients. The serum omentin-1 level was found to be associated with cardio metabolic disorders. The aim of this study was to examine the clinical significance of omentin-1 and other the most common risk factors of morbidity and mortality and identify independent predictors of haemodialysis treatment outcome. Methods: There were 120 patients (at baseline) included in the study and 84 were analyzed at the end of the follow-up (after 18 months). Participants were divided into two groups: diabetes positive and diabetes negative. Venous blood was withdrawn after an overnight fasting before dialysis session. Serum omentin-1 levels were assessed using a commercial enzyme-linked immunosorbent assay. Results: Omentin-1 levels of diabetic ESRD patients after 18 months were found to be lower than of non diabetic ESRD patients (9.1±5.8 ng/ml vs. 11.4±4.1 ng/ml, respectively ; P=0.015). Also, serum omentin-1 levels on the same surviving patients population after 18 months were lower in diabetes negative (11.4±4.1 ng/ml vs. 15.0±5.1 ng/ml, respectively ; P<0.001) and in diabetes positive group (9.1±5.8 ng/ml vs. 13.8±5.9 ng/ml, respectively ; P=0.003). Conclusions: Our study demonstrated that omentin-1 levels are independent mortality risk factor in non diabetic ESRD patients. We believe that in these patients group, decreased omentin-1 levels plays a important role in progression of atherosclerosis through its action on the vascular endothelial inflammatory state.

omentin ; diabetes ; haemodialysis

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