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Pregled bibliografske jedinice broj: 724765

An update on the management of young-onset Parkinson's disease

Klepac, Nataša; Habek, Mario; Adamec, Igor; Barušić, Anabela Karla; Bach, Ivo; Margetić, Eduard; Lušić, Ivo
An update on the management of young-onset Parkinson's disease // Degenerative neurological and neuromuscular disease, 3 (2013), 53-62 doi:10.2147/DNND.S34251 (međunarodna recenzija, članak, znanstveni)

An update on the management of young-onset Parkinson's disease

Klepac, Nataša ; Habek, Mario ; Adamec, Igor ; Barušić, Anabela Karla ; Bach, Ivo ; Margetić, Eduard ; Lušić, Ivo

Degenerative neurological and neuromuscular disease (1179-9900) 3 (2013); 53-62

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Parkinson disease; management; therapy; clinical features; dopamine agonist; levodopa; dyskinesia

In the text that follows, we review the main clinical features, genetic characteristics, and treatment options for Parkinson's disease (PD), considering the age at onset. The clinical variability between patients with PD points at the existence of subtypes of the disease. Identification of subtypes is important, since a focus on homogenous group may lead to tailored treatment strategies. One of the factors that determine variability of clinical features of PD is age of onset. Young-onset Parkinson's disease (YOPD) is defined as parkinsonism starting between the ages of 21 and 40. YOPD has a slower disease progression and a greater incidence and earlier appearance of levodopa-induced motor complications ; namely, motor fluctuations and dyskinesias. Moreover, YOPD patients face a lifetime of a progressive disease with gradual worsening of quality of life and their expectations are different from those of their older counterparts. Knowing this, treatment plans and management of symptoms must be paid careful attention to in order to maintain an acceptable quality of life in YOPD patients.

Izvorni jezik

Znanstvena područja
Kliničke medicinske znanosti


KBC Split,
Medicinski fakultet, Split

Časopis indeksira:

  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
    • Emerging Sources Citation Index (ESCI)

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