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REGULATION OF MITOPHAGY RECEPTORS BY PHOSPHORYLATION (CROSBI ID 616276)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa

Novak, Ivana ; Fischkin, Evgeni ; Marinković, Mija ; Hamacher-Brady, Anne ; Brady Nathan ; Đikić, Ivan REGULATION OF MITOPHAGY RECEPTORS BY PHOSPHORYLATION. 2012. str. 1-2

Podaci o odgovornosti

Novak, Ivana ; Fischkin, Evgeni ; Marinković, Mija ; Hamacher-Brady, Anne ; Brady Nathan ; Đikić, Ivan

engleski

REGULATION OF MITOPHAGY RECEPTORS BY PHOSPHORYLATION

Recent discoveries of autophagic receptors that recognize specific cellular cargo have opened a new chapter in autophagy field. Selective removal of damaged organelles or protein aggregates is essential for the proper cellular homeostasis and survival. We have recently identified and characterized Nix/Bnip3L mitochondrial protein as mitophagy receptor that, in LIR-dependent manner, interacts with LC3/GABARAP proteins and recruits autophagy machinery to damaged mitochondria. Moreover, we have shown that Nix mediates mitochondrial clearance during reticulocyte differentiation. Recent discovery of Optn, an autophagy receptor involved in recognition of intracellular bacteria, showed that its autophagic function is regulated by phosphorylation of the LIR motif. We are investigating the phosphorylation status of Nix and its homolog Bnip3 in regulation of mitophagy. Our preliminary results indicate that phosphorylation of mitophagy receptors Nix and Bnip3 is involved in fine tuning of mitophagy.

mitophagy ; autophagy ; mitochondria

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Podaci o prilogu

1-2.

2012.

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objavljeno

Podaci o matičnoj publikaciji

Podaci o skupu

PTMs in Cell Signaling

poster

02.12.2012-05.12.2012

Kopenhagen, Danska

Povezanost rada

Biologija