REGULATION OF MITOPHAGY RECEPTORS BY PHOSPHORYLATION (CROSBI ID 616276)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa
Podaci o odgovornosti
Novak, Ivana ; Fischkin, Evgeni ; Marinković, Mija ; Hamacher-Brady, Anne ; Brady Nathan ; Đikić, Ivan
engleski
REGULATION OF MITOPHAGY RECEPTORS BY PHOSPHORYLATION
Recent discoveries of autophagic receptors that recognize specific cellular cargo have opened a new chapter in autophagy field. Selective removal of damaged organelles or protein aggregates is essential for the proper cellular homeostasis and survival. We have recently identified and characterized Nix/Bnip3L mitochondrial protein as mitophagy receptor that, in LIR-dependent manner, interacts with LC3/GABARAP proteins and recruits autophagy machinery to damaged mitochondria. Moreover, we have shown that Nix mediates mitochondrial clearance during reticulocyte differentiation. Recent discovery of Optn, an autophagy receptor involved in recognition of intracellular bacteria, showed that its autophagic function is regulated by phosphorylation of the LIR motif. We are investigating the phosphorylation status of Nix and its homolog Bnip3 in regulation of mitophagy. Our preliminary results indicate that phosphorylation of mitophagy receptors Nix and Bnip3 is involved in fine tuning of mitophagy.
mitophagy ; autophagy ; mitochondria
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
1-2.
2012.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Podaci o skupu
PTMs in Cell Signaling
poster
02.12.2012-05.12.2012
Kopenhagen, Danska