Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

THE ROLE OF AUTOPHAGY RECEPTORS IN SELECTIVE REMOVAL OF MITOCHONDRIA (CROSBI ID 616275)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa

Marinković, Mija ; Terzić, Janoš ; Hamacher-Brady, Anne ; Brady, Nathan ; Dikic, Ivan ; Novak, Ivana THE ROLE OF AUTOPHAGY RECEPTORS IN SELECTIVE REMOVAL OF MITOCHONDRIA // HDBMB2014 „The Interplay of Biomolecules“ / Maja Katalinić and Zrinka Kovarik (ur.). Zagreb: Hrvatsko Društvo za Biotehnologiju, 2014. str. 39-39

Podaci o odgovornosti

Marinković, Mija ; Terzić, Janoš ; Hamacher-Brady, Anne ; Brady, Nathan ; Dikic, Ivan ; Novak, Ivana

engleski

THE ROLE OF AUTOPHAGY RECEPTORS IN SELECTIVE REMOVAL OF MITOCHONDRIA

Recent discoveries of autophagic receptors that recognize specific cellular cargo have opened a new chapter in autophagy field. Selective removal of damaged organelles or protein aggregates is essential for the proper cellular homeostasis and survival. We have recently identified and characterized Nix/Bnip3L mitochondrial protein as mitophagy receptor that, in LIR - dependent manner, interacts with LC3/GABARAP proteins and recruits autophagy machinery to damaged mitochondria. Moreover, we have shown that Nix mediates mitochondrial clearance during reticulocyte differentiation. Additionally, Nix forms strong homodimers and we propose that Nix dimerization is required for the recruitment of LC3/GABARAP to damaged mitochondria and is a trigger for mitophagy. Recent discovery of Optn, an autophagy receptor involved in recognition of intracellular bacteria, showed that its autophagic function is regulated by phosphorylation of the LIR motif. We are investigating the phosphorylation status of Nix and its homolog Bnip3 in regulation of mitophagy. Our preliminary results indicate that phosphorylation of mitophagy receptors Nix and Bnip3 is involved in fine tuning of mitophagy.

mitophagy ; autophagy ; mitochondria

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

39-39.

2014.

nije evidentirano

objavljeno

978-953-95551-5-1

Podaci o matičnoj publikaciji

HDBMB2014 „The Interplay of Biomolecules“

Maja Katalinić and Zrinka Kovarik

Zagreb: Hrvatsko Društvo za Biotehnologiju

Podaci o skupu

Congress of the Croatian Society of Biochemistry and Molecular Biology “The Interplay of Biomolecules”, HDBMB2014

pozvano predavanje

24.09.2014-27.09.2014

Zadar, Hrvatska

Povezanost rada

Biologija, Temeljne medicinske znanosti