engleski

Rat cardiac imaging - coregistered 18FGD-PET and gold nanoparticles CT

Positron emission tomography (PET) is a method of nuclear medicine that allows to determine spatial and temporal distribution of radiolabelled molecules - radiopharmaceuticals. The most commonly used radiopharmaceutical in the PET imaging is a glucose analogue 2-fluoro- 2-deoxy-glucose (18FDG). 18FGD-PET imaging enables visualization of glucose metabolism and it is considered as a functional imaging. On the other hand, computed tomography (CT) provides insight in tissue morphology and it represents typical anatomical imaging. Native CT is not a method of choice for displaying the rat heart anatomy, but CT with gold nanoparticles (GNP) as an contrast agent becomes very useful cardiac imaging method. When GNP is applied intravenously, because of the high absorption of x-rays and low interaction with the tissues, it becomes an excellent contrast agent for x-ray, including CT. The presence of GNP in the bloodstream provides a detailed display of the blood vessels with high contrast. The combination of functional and anatomical imaging methods is often used in research and diagnostics. The overlaping of images from different imaging methods with anatomical accuracy, is called coregistration. Coregistered PET and CT images together provide much more information than PET or CT separately. Applied in cardiology, 18FDG- PET displays the glucose uptake in the myocardium while GNP-CT provides a very detailed view of the blood vessels at the base of the heart and cardiac chambers, especially the ventricles. Successfully coregistered 18FDG-PET and GNP-CT images represent an excellent method in cardiology preclinical research.

Positron emission tomography ; cardiac 18FDG-PET ; rat ; GNP contrast CT

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