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Pregled bibliografske jedinice broj: 724119

The Exploitation of Toll-like Receptor 3 Signaling in Cancer Therapy


Matijević Glavan, Tanja; Pavelić, Jasminka
The Exploitation of Toll-like Receptor 3 Signaling in Cancer Therapy // Current pharmaceutical design, 20 (2014), 4; 6555-6564 doi:10.2174/1381612820666140826153347 (međunarodna recenzija, pregledni rad, znanstveni)


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Naslov
The Exploitation of Toll-like Receptor 3 Signaling in Cancer Therapy

Autori
Matijević Glavan, Tanja ; Pavelić, Jasminka

Izvornik
Current pharmaceutical design (1381-6128) 20 (2014), 4; 6555-6564

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Toll-like receptor 3; Signaling; Cancer; Therapy; Poly (I:C)

Sažetak
Toll-like receptors (TLRs) are a group of transmembrane receptors that recognize molecular motifs of pathogen origin and activate immune response. Although TLRs were first identified in immune system cells, recent studies show they can also be expressed in tumor cells. TLR3 recognizes dsRNA or its synthetic ligand poly (I:C) and is responsible primarily for the defense against viral infections. Recent studies showed that TLR3 can trigger apoptosis in cancer cell. Furthermore, other dsRNA binding receptors (MDA5 and RIG-I), localized in cytoplasm, can also bind poly (I:C) and therefore contribute to this effect. With TLR3’s capacity to induce apoptosis and activate the immune system at the same time, TLR3 ligands are an attractive therapeutic option for treatment of cancer. Novel therapies include combining poly (I:C) with other components such as chemotherapeutics, apoptosis enhancers, other TLR ligands and peptides activating the immune system. Slightly modified TLR3 agonists (Ampligen®, Hiltonol®, poly IC-LC) are already being used in clinical studies for cancer therapy as single agents or in combination with other drugs. On the other hand, latest studies forewarn that TLR3 activation can also have tumor promoting role so it is crucial to identify the terms by which TLR3 has pro-tumor/anti-tumor effect in order to safely implement TLR3 ligand based therapy into clinical trials.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2394 - Gensko liječenje tumora djelovanjem na molekule imunološkog sustava (Pavelić, Jasminka, MZOS - )

Ustanove
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Matijević Glavan, Tanja; Pavelić, Jasminka
The Exploitation of Toll-like Receptor 3 Signaling in Cancer Therapy // Current pharmaceutical design, 20 (2014), 4; 6555-6564 doi:10.2174/1381612820666140826153347 (međunarodna recenzija, pregledni rad, znanstveni)
Matijević Glavan, T. & Pavelić, J. (2014) The Exploitation of Toll-like Receptor 3 Signaling in Cancer Therapy. Current pharmaceutical design, 20 (4), 6555-6564 doi:10.2174/1381612820666140826153347.
@article{article, year = {2014}, pages = {6555-6564}, DOI = {10.2174/1381612820666140826153347}, keywords = {Toll-like receptor 3, Signaling, Cancer, Therapy, Poly (I:C)}, journal = {Current pharmaceutical design}, doi = {10.2174/1381612820666140826153347}, volume = {20}, number = {4}, issn = {1381-6128}, title = {The Exploitation of Toll-like Receptor 3 Signaling in Cancer Therapy}, keyword = {Toll-like receptor 3, Signaling, Cancer, Therapy, Poly (I:C)} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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