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Pregled bibliografske jedinice broj: 723914

Kinetic and flow injection spectrophotometric determination of N-acetylcysteine ethyl ester based on the reduction of copper(II)-neocuproine


Kukoč-Modun, Lea; Tsikas, Dimitrios; Kraljević, Tomislav; Biočić, Maja; Radić, Njegomir
Kinetic and flow injection spectrophotometric determination of N-acetylcysteine ethyl ester based on the reduction of copper(II)-neocuproine // Bulletin of the Chemists and Technologists of Bosnia and Herzegovina / Korać, Fehim (ur.).
Sarajevo: Prirodno-matematički fakultet Sarajevo, 2014. str. 59-59 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Kinetic and flow injection spectrophotometric determination of N-acetylcysteine ethyl ester based on the reduction of copper(II)-neocuproine

Autori
Kukoč-Modun, Lea ; Tsikas, Dimitrios ; Kraljević, Tomislav ; Biočić, Maja ; Radić, Njegomir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Bulletin of the Chemists and Technologists of Bosnia and Herzegovina / Korać, Fehim - Sarajevo : Prirodno-matematički fakultet Sarajevo, 2014, 59-59

Skup
Congress of Chemists and Chemical Engineers of Bosnia and Herzegovina with International Participation

Mjesto i datum
Sarajevo, Bosna i Hercegovina, 10-12.10.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
N-Acetylcysteine ethyl ester; Kinetic spectrophotometry; Fixed time method; Flow injection.

Sažetak
Kinetic spectrophotometric and flow injection methods of analysis were developed for the determination of a novel lipophilic cell-permeable cysteine derivative N-acetylcysteine ethyl ester (NACET). The proposed methods are based on a reduction reaction of Cu(II)-neocuproine reagent to Cu(I)-neocuproine by NACET in a Britton-Robinson buffer solution. The absorbance of the generated Cu(I)-neocuproine complex is measured at 458 nm. In the kinetic procedure a fixed time method was utilized for the construction of calibration graphs, and the recorded peak height was used as a quantitative variable in the flow injection procedure. A linear calibration graph was obtained from 1.0×10-6 to 1.0×10-4 mol L–1 of NACET by the use of the kinetic spectrophotometric method where the detection limit was 4.7×10-8 mol L-1. The linearity of the proposed flow injection method was obtained over the range 2.0×10-6 mol L-1 – 6.0×10-5 mol L-1 NACET, where the limit of detection was 2.7×10-7 mol L-1.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
011-0000000-3217 - Određivanje tiola primjenom potenciometrijskih senzora i spektroskopije (Njegomir Radić, )

Ustanove
Kemijsko-tehnološki fakultet, Split