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Pregled bibliografske jedinice broj: 722636

Matrix metalloproteinases and E-cadherin immunoreactivity in different basal cell carcinoma histological types


Vanjaka-Rogošić, Lucija; Puizina-Ivić, Neira; Mirić, Lina; Rogošić, Veljko; Kuzmić-Prusac, Ivana; Saraga-Babić, Mirna; Vuković, Dubravka; Mardešić, Snježana
Matrix metalloproteinases and E-cadherin immunoreactivity in different basal cell carcinoma histological types // Acta Histochemica, 116 (2014), 5; 688-693 doi:10.1016/j.acthis.2013.12.007 (međunarodna recenzija, članak, znanstveni)


Naslov
Matrix metalloproteinases and E-cadherin immunoreactivity in different basal cell carcinoma histological types

Autori
Vanjaka-Rogošić, Lucija ; Puizina-Ivić, Neira ; Mirić, Lina ; Rogošić, Veljko ; Kuzmić-Prusac, Ivana ; Saraga-Babić, Mirna ; Vuković, Dubravka ; Mardešić, Snježana

Izvornik
Acta Histochemica (0065-1281) 116 (2014), 5; 688-693

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Basal cell carcinoma; MMP-1; MMP-2; MMP-9; MMP-13; E-cadherin

Sažetak
The immunohistochemical staining of matrix metalloproteinases (MMPs) and E-cadherin in tumor epithelial and stromal cells was analyzed in a group of solid, superficial spreading and cystic tumors and in a group of morpheaform and recurrent basal cell carcinomas (BCC) in order to determine whether any of these factors possibly contribute to tumor therapy resistance. Tumor tissues of 64 patients were obtained by complete excisional or curettage biopsy of BCC and these were immunohistochemically stained for MMP-1, MMP-2, MMP-9, MMP-13 and E-cadherin. In the morpheaform and recurrent BCC, MMP-9 expression significantly increased in the stroma, while E-cadherin expression was negative in epithelial cells. Odds ratio for development of morpheaform and recurrent BCC was 6.2 for positive MMP-1 immunostaining in epithelial tumor cells, 5.8 for positive MMP-9 immunostaining in tumor stroma, 3.2 for positive MMP-13 immunostaining in tumor stroma, and 4.5 for negative E-cadherin in epithelial tumor cells. Our results suggest that MMP-1 immunostaining in tumor cells, MMP-9 expression in stromal cells, and absence of E-cadherin expression are associated with morpheaform and recurrent BCC.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
216-2160528-0507 - Genski izražaj u ranom razvoju čovjeka (Mirna Saraga-Babić, )

Ustanove
Medicinski fakultet, Split

Citiraj ovu publikaciju

Vanjaka-Rogošić, Lucija; Puizina-Ivić, Neira; Mirić, Lina; Rogošić, Veljko; Kuzmić-Prusac, Ivana; Saraga-Babić, Mirna; Vuković, Dubravka; Mardešić, Snježana
Matrix metalloproteinases and E-cadherin immunoreactivity in different basal cell carcinoma histological types // Acta Histochemica, 116 (2014), 5; 688-693 doi:10.1016/j.acthis.2013.12.007 (međunarodna recenzija, članak, znanstveni)
Vanjaka-Rogošić, L., Puizina-Ivić, N., Mirić, L., Rogošić, V., Kuzmić-Prusac, I., Saraga-Babić, M., Vuković, D. & Mardešić, S. (2014) Matrix metalloproteinases and E-cadherin immunoreactivity in different basal cell carcinoma histological types. Acta Histochemica, 116 (5), 688-693 doi:10.1016/j.acthis.2013.12.007.
@article{article, year = {2014}, pages = {688-693}, DOI = {10.1016/j.acthis.2013.12.007}, keywords = {Basal cell carcinoma, MMP-1, MMP-2, MMP-9, MMP-13, E-cadherin}, journal = {Acta Histochemica}, doi = {10.1016/j.acthis.2013.12.007}, volume = {116}, number = {5}, issn = {0065-1281}, title = {Matrix metalloproteinases and E-cadherin immunoreactivity in different basal cell carcinoma histological types}, keyword = {Basal cell carcinoma, MMP-1, MMP-2, MMP-9, MMP-13, E-cadherin} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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