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Pregled bibliografske jedinice broj: 722511

Isotropic actomyosin dynamics promote organization of the apical cell cortex in epithelial cells


Klingner, C.; Cherian, A.V.; Fels, J.; Diesinger, P.M.; Aufschnaiter, R.; Maghelli, N.; Keil, T.; Beck, G.; Tolić-Nørrelykke, Iva Marijha; Bathe, M.; Wedlich-Soldner, R.
Isotropic actomyosin dynamics promote organization of the apical cell cortex in epithelial cells // The Journal of cell biology, 207 (2014), 1; 107-121 doi:10.1083/jcb.201402037 (međunarodna recenzija, članak, znanstveni)


Naslov
Isotropic actomyosin dynamics promote organization of the apical cell cortex in epithelial cells

Autori
Klingner, C. ; Cherian, A.V. ; Fels, J. ; Diesinger, P.M. ; Aufschnaiter, R. ; Maghelli, N. ; Keil, T. ; Beck, G. ; Tolić-Nørrelykke, Iva Marijha ; Bathe, M. ; Wedlich-Soldner, R.

Izvornik
The Journal of cell biology (0021-9525) 207 (2014), 1; 107-121

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Actin ; cortex ; microvilli ; myosin II ; laser ablation

Sažetak
Although cortical actin plays an important role in cellular mechanics and morphogenesis, there is surprisingly little information on cortex organization at the apical surface of cells. In this paper, we characterize organization and dynamics of microvilli (MV) and a previously unappreciated actomyosin network at the apical surface of Madin-Darby canine kidney cells. In contrast to short and static MV in confluent cells, the apical surfaces of nonconfluent epithelial cells (ECs) form highly dynamic protrusions, which are often oriented along the plane of the membrane. These dynamic MV exhibit complex and spatially correlated reorganization, which is dependent on myosin II activity. Surprisingly, myosin II is organized into an extensive network of filaments spanning the entire apical membrane in nonconfluent ECs. Dynamic MV, myosin filaments, and their associated actin filaments form an interconnected, prestressed network. Interestingly, this network regulates lateral mobility of apical membrane probes such as integrins or epidermal growth factor receptors, suggesting that coordinated actomyosin dynamics contributes to apical cell membrane organization.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Biologija



POVEZANOST RADA


Ustanove
Institut "Ruđer Bošković", Zagreb

Autor s matičnim brojem:
Iva Marija Tolić, (260543)

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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