engleski

Effects of metformin and insulin administration on expression of adhesion molecules on endothelial cells in mild hyperhomocysteinemia and hyperglycaemia.

One of the major pathogenic mechanisms of atherosclerosis is the recruitment of circulating leukocytes to the blood vessel wall and their subsequent migration into the subendothelial spaces. This process is predominantly mediated by cellular adhesion molecules, which are expressed on both the vascular endothelium and the leukocytes in response to several atherogenic stimuli.Metformin and insulin did not decrease CAMs in mild hyperhomocysteinemia and hyperglicemya. In defined conditions they have not anti-inflammatory and anti-atherogenic effects which could contribute to development of macrovascular complications in diabetic patients who have two or more risk factor of atherosclerosis.

metformin ; insulin ; adhesion molecules ; endothelial cells

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