engleski

Plasma content of glucose, C-reactive protein, uric acid and Cholesterol in male, female and ovariectomized rats upon acute and Chronic stress – a path for development of cardiovascular diseases

To explore sex differences in cardiovascular function under stress, we analyzed plasma levels of glucose, C-reactive protein (CRP), uric acid and cholesterol in male, female and ovariectomized rats under acute and chronic stress. Glucose tolerance test (GTT) was performed in all rats before any stress was inflicted, as well as later in chronic stress experiment. GTT in control animals showed the same trend as in chronically stressed. Male rats showed the highest plasma level of glucose and uric acid at acute stress in comparison with the other two groups. Ovariectomized rats reached the highest value of plasma cholesterol during acute and chronic stress and also the highest plasma level of CRP during acute stress. Stress, as a risk factor of metabolic syndrome affected biochemical parameters in males under acute stress more then under chronic, but the opposite was observed in female rats. Ovariectomy was additional factor in continuous stress, having the highest impact on plasma levels of cholesterol and CRP.

Cardiovascular diseases; chronic stress; acute stress; cholesterol; glucose; uric acid; C- reactive protein; ovariectomy; estrogen; plasma

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