engleski

Expression of myogenic transcriptional factors in rat skeletal muscles

The family of muscle specific basic helix-loop-helix (bHLH) regulatory factors consists of MyoD, Myf-5, myogenin and MRF-4. These factors contribute to the transcriptional activation of muscle genes during commitment and differentiation. Each of these myogenic bHLH proteins form a heterodimer complex that builds DNA, and includes other bHLH proteins E2 gene family and builds canonical DNA sequence, CANNTG (E box) within the gene enhancing elements that encode markers of terminal differentiation of skeletal muscle. A distinct role for the bHLH myogenic factors initially was suggested by their different temporal expression patterns in the somites and limbs during embryonic development. Gene knock out experiments provided evidence for the role of MyoD and Myf-5 in myoblast commitment, whereas myogenin is required for terminal myoblast differentiation. Myogenic transcriptional factors are involved in the process of the muscle denervation and regeneration on the protein or on the transcriptional level.

myogenic transcriptional factors; skeletal muscle; rat

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