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The influence of anemia and applied dialysis technique on clinical and neurophysiological indicators of uremic polyneuropathy in dialysis patients

Uremic polyneuropathy is the most recurring neurological complication in cronic renal failure (CRF). 90% of patients with CRF have anemia. The aim was to estimate the influence of anemia and dialysis on the severity of polyneuropathy. Two times we examined 90 non-diabetic patients who were suffering from uremic polyneuropathy and CFR, and treated by repeated dialysis. The were clinically and electromyneurographicallyexmined, all patients had their hemoglobin levels determined. We did not find significant distinction in clinical symptoms and signs of polyneuropathy between anemic and non-anemic patients. We compered electroneurographic parameters for patients who were anemic during the whole monitoring period to those who were non-anemic. We obtained much better findings (P<0.005) for: the sensor conduction velocity of n. medianus, ulnaris, suralis ; the amplitude of the muscle response of the n. medianus, the latences of F waves for non-anemic patients. The hemoglobin value is stable when dialysis duration is more than 6 years (P<0.001). We obtained better findings (P<0.005) for: motor conduction velocity of the n. peroneus, tibialis, and for sensor conduction velocity of the n. suralis for patients on hemodialysis compared with patients on peritoneal dialysis. Our patients on peritoneal dialysis were both much older and had a longer dialysis duration, we could not conclude that dialysis has a considerable effect on the severity of polyneuropathy. Anemia deteriorates electroneurographic parameters of uremic polyneuropathy. When hemoglobin level is stable, the other effects on the progression of polyneuropathy are advanced age and longer contact with the dialysis membrane.

anemia; applied dialysis technique; uremic polyneuropathy

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