engleski

Honeydew honey as a potential agent against drug - resistant bacteria

Strains of methicillin-resistant Staphylococcus aureus and multidrug-resistant Acinetobacter baumannii have become increasingly common and the spread of these represents a serious health threat. Since ancient times, honey has been known to possess antimicrobial properties. The objectives of this study were to test the antibacterial activity of honeydew honey against drug resistant A. baumannii and S. aureus. Using a broth dilution method, the antibacterial activity of 7 different type of honeydew honey, 6 samples of fir honeydew – Abies alba Mill and maple honeydew (Acer spp., chestnut – Castanea sativa Mill), against multi-drug resistant and drug sensitive strains of A. baumannii and S. aureus was determined. Different concentrations of honey (0, 025 g/ml – 0, 4 g/ml) were tested against each bacterial strain. The minimum inhibitory concentration (MIC) were determined by visual inspection as the lack of visual turbidity and minimum bactericidal concentration (MBC) also was determined by culturing on blood agar plates. Our result showed that all tested A. baumannii and S. aureus strains were sensitive to fir honeydew regardless of the resistance. The lowest MIC value of 0, 025 g/ml and MBC value of 0, 05 g/mL for fir honeydew honeys was against multi-drug resistant A. baumannii as well as MRSA. In summary, we showed that fir honeydew possesses strong bactericidal activity against drug resistant bacteria, A. baumannii and S. aureus. Thus, this honey has excellent potential as an anti-infective agent for infections caused by antibiotic-susceptible or -resistant bacteria. However, this approach needs to be further studied.

honeydew; antibacterial effect; drug – resistant bacteria; therapy

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