engleski

Endothelial dysfunction and systemic inflammation in different COPD phenotypes.

Background: Endothelial dysfunction is a possible link between increased cardiovascular mortality and systemic inflammation in patients with COPD. Previous studies suggest an association between acute exacerbation of COPD and deterioration of endothelial function, but so far systematic studies of endothelial dysfunction in two phenotypically distinct groups of COPD patients has not been done. Aim: The aim of this study was to investigate whether there are differences in endothelial function and systemic inflammation between the two groups of COPD patients: „frequent exacerbator“ and „infrequent exacerbator“. Methods: 117 patients were enrolled. COPD patients were divided into two groups according to the criteria of frequency of acute exacerbation: 41 „frequent exacerbator“ and 41 „infrequent exacerbator“. The control group consists of 35 healthy smokers. In all three groups were determined vWF as a marker of endothelial dysfunction and CRP and fibrinogen as markers of systemic inflammation. Results: We found an increase of all markers of endothelial function and sistemic inflammation in the „frequent exacerbator“ group compared to the “infrequent exacerbator“ group and compared to the healthy control group ( vWF 181.0 vrs 157.5 vrs 132.1, CRP 5.6 vrs 2.7 vrs 1.7, fibrinogen 4.8 vrs 4.1 vrs 3.7). The differences found were statistically significant in all cases (p<0, 001). Conclusion: Between the two phenotypic groups of COPD patients, there is a difference in the degree of endothelial dysfunction and systemic inflammation.

Lung disease obstructive; Phenotype; Inflammation; Endothelial dysfunction

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