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Genotoxic effects of ZnO nanoparticles im male Wistar rats


Kašuba, Vilena; Želježić, Davor; Mladinić, Marin; Rozgaj, Ružica; Milić, Mirta; Kopjar, Nevenka; Micek, Vedran.
Genotoxic effects of ZnO nanoparticles im male Wistar rats // Toxicology Letters 229S (2014) S194. Abstracts of the 50th Congress of the European Societies of Toxicology (EUROTOX) / Kehrer JP, Dekant W, Li Y, Smith CV, Panagiotidis MI, Menzel DB. (ur.).
2014 Elsevier Ireland Ltd.: Elsevier, 2014. str. S194-S194 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Genotoxic effects of ZnO nanoparticles im male Wistar rats

Autori
Kašuba, Vilena ; Želježić, Davor ; Mladinić, Marin ; Rozgaj, Ružica ; Milić, Mirta ; Kopjar, Nevenka ; Micek, Vedran.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Toxicology Letters 229S (2014) S194. Abstracts of the 50th Congress of the European Societies of Toxicology (EUROTOX) / Kehrer JP, Dekant W, Li Y, Smith CV, Panagiotidis MI, Menzel DB. - 2014 Elsevier Ireland Ltd. : Elsevier, 2014, S194-S194

Skup
The 50th Congress of the European Societies of Toxicology (EUROTOX 2014)

Mjesto i datum
Edinburg, Škotska, 07.- 10.09.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Zinc oxide; genotoxicity; nanoparticles; in vivo

Sažetak
Zinc oxide nanoparticles (ZnO NPs) find applications in industry and medicine. The use of nanomaterials has led to the growing concern about their toxicity. Present in vivo study in 10 weeks old male Wistar rats was aimed at investigating the oral toxicty of nano sized ZnO (<35 nm). The genotoxic potential was determined using the alkaline comet assay on kidney, liver and brain cells, and blood lymphocytes. The permanent DNA damage was assessed using the in vivo MN asay in blood. Rats were administered with ZnONPs water dispersion at 5, 10 and 50 mgkg-1bw- 1 daily, or water only for 28 consecutive days through oral gavage. Ethyl methanesulphonate (EMS) as a positive control was given in three daily doses of 300 mgkg-1bw-1 begining at 25.day. For statistical analysis ANOVA and Kruskal-Wallis test were applied. Kidney and brain showed significantly higher values of Tail Intensity (TI) at concentrations of 5 and 50 mgkg-1bw-1 as compared to control. Blood sample significantly differed in TI at a concentration of 50 mgkg-1 compared to all other concentrations including control. All applied concentrations of ZnO NPs in liver significantly increased TI compared to control. MN in vivo test in both erythrocytes and reticulocytes showed significant differences between the highest ZnO NPs concentration and all other applied concentrations. Further in vivo studies with the implementation of new biomarkers should validate these results.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekt / tema
022-0222148-2137 - Genotoksičnost kemijskih i fizikalnih agensa prirodnog i antropogenog podrijetla (Vilena Kašuba, )

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE