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Pregled bibliografske jedinice broj: 718306

Adjunctive Madopar for ultrarefractory epilepsy ? Preliminary observations


Hodoba, Danilo; Šantić, Ana Marija; Schmidt, Dieter
Adjunctive Madopar for ultrarefractory epilepsy ? Preliminary observations // Epilepsy & behavior, 28 (2013), 2; 201-202 doi:10.1016/j.yebeh.2013.05.015 (međunarodna recenzija, kratko priopcenje, znanstveni)


Naslov
Adjunctive Madopar for ultrarefractory epilepsy ? Preliminary observations

Autori
Hodoba, Danilo ; Šantić, Ana Marija ; Schmidt, Dieter

Izvornik
Epilepsy & behavior (1525-5050) 28 (2013), 2; 201-202

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
Madopar; Refractory epilepsy; Drug-resistant epilepsy; Ultrarefractory epilepsy; Seizure control; Dopaminergic

Sažetak
The optimum drug treatment for ultrarefractory epilepsy after failure of seven prior antiepileptic drugs (AEDs) remains uncertain. Prompted by reports that adjunctive amantadine or L-dopa has been useful for children with refractory absence seizures and Lennox–Gastaut syndrome, we studied the utility of dopaminergic agents for adults with ultrarefractory epilepsy. Methods: We assessed seizure control following adjunctive treatment for up to 12 months with the dopaminergic agent Madopar© in three adult patients with ultrarefractory epilepsy following brain injury or with Lennox–Gastaut syndrome, who had not achieved sustained seizure remission during past treatment with at least seven lifetime AEDs. Findings: The adjunctive use of Madopar was associated with a reduction or remission of tonic–clonic seizures in two patients. However, Madopar seemed to have aggravated absence seizures in the patient with Lennox– Gastaut syndrome. Interpretation: Although our preliminary observations do not and cannot establish the efficacy or safety of adjunctive Madopar, it may be an option for treatment of ultrarefractory focal seizures in adults if confirmed by randomized controlled trials.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Klinika za psihijatriju Vrapče

Autor s matičnim brojem:
Ana Šantić, (236704)
Danilo Hodoba, (2421)

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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