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Merotelic kinetochore attachment: causes and effects


Gregan, Juraj; Polakova, Silvia; Zhang, Lijuan; Tolić-Norrelykke, Iva M.; Cimini, Daniela
Merotelic kinetochore attachment: causes and effects // Trends in cell biology, 21 (2011), 6; 374-381 doi:10.1016/j.tcb.2011.01.003 (međunarodna recenzija, pregledni rad, znanstveni)


Naslov
Merotelic kinetochore attachment: causes and effects

Autori
Gregan, Juraj ; Polakova, Silvia ; Zhang, Lijuan ; Tolić-Norrelykke, Iva M. ; Cimini, Daniela

Izvornik
Trends in cell biology (0962-8924) 21 (2011), 6; 374-381

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Chromosome segregation

Sažetak
Accurate chromosome segregation depends on the proper attachment of sister kinetochores to microtubules emanating from opposite spindle poles. Merotelic kinetochore orientation is an error in which a single kinetochore is attached to microtubules emanating from both spindle poles. Despite correction mechanisms, merotelically attached kinetochores can persist until anaphase, causing chromatids to lag on the mitotic spindle and hindering their timely segregation. Recent studies showing that merotelic kinetochore attachment represents a major mechanism of aneuploidy in mitotic cells and is the primary mechanism of chromosomal instability in cancer cells have underlined the importance of studying merotely. Here, we highlight recent progress in our understanding of how cells prevent and correct merotelic kinetochore attachments.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Biologija



POVEZANOST RADA


Autor s matičnim brojem:
Iva Marija Tolić, (260543)

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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