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Synthesis og farmaceutically Active Amidino Substituted Heterocyclic Benzothiazoles (CROSBI ID 481632)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Racane, Livio ; Tralić-Kulenovć, Vesna ; Karminski-Zamola, Grace Synthesis og farmaceutically Active Amidino Substituted Heterocyclic Benzothiazoles // 12th European Symposium on Organic Chemistry : Book of abstracts / Feringa, Ben L. (ur.). Groningen, 2001. str. 60-60

Podaci o odgovornosti

Racane, Livio ; Tralić-Kulenovć, Vesna ; Karminski-Zamola, Grace

engleski

Synthesis og farmaceutically Active Amidino Substituted Heterocyclic Benzothiazoles

A number of substituted benzothiazoles exhibit useful pharmacological activities. Continuing our studies on the synthesis of some effective, compounds against cancer we prepared some new heterocyclic diamidines. Starting with 5-(p-cyanophenyl)-2-thiophene (or furan)carbaldehyde and with p-(carboxyphenyl)-2-thiophene or (furan)carbonitrilby multistep synthesis we obtained corresponding dinitriles. Diamidines were prepared by the reacrion of diimidate derivatives with isopropylamine or ethylenediamine, respectively (Pinner reaction). The free base was treated with HCl to generate the water soluble bis-hyrdochloride salts.

amidines ; benzothiazoles ; furans ; thiophenes ; anti-HIV substances

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Podaci o prilogu

60-60.

2001.

objavljeno

Podaci o matičnoj publikaciji

12th European Symposium on Organic Chemistry : Book of abstracts

Feringa, Ben L.

Groningen:

Podaci o skupu

The 12th European Symposium on Organic Chemistry

poster

13.07.2001-18.07.2001

Groningen, Nizozemska

Povezanost rada

Kemija