Synthesis og farmaceutically Active Amidino Substituted Heterocyclic Benzothiazoles (CROSBI ID 481632)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Racane, Livio ; Tralić-Kulenovć, Vesna ; Karminski-Zamola, Grace
engleski
Synthesis og farmaceutically Active Amidino Substituted Heterocyclic Benzothiazoles
A number of substituted benzothiazoles exhibit useful pharmacological activities. Continuing our studies on the synthesis of some effective, compounds against cancer we prepared some new heterocyclic diamidines. Starting with 5-(p-cyanophenyl)-2-thiophene (or furan)carbaldehyde and with p-(carboxyphenyl)-2-thiophene or (furan)carbonitrilby multistep synthesis we obtained corresponding dinitriles. Diamidines were prepared by the reacrion of diimidate derivatives with isopropylamine or ethylenediamine, respectively (Pinner reaction). The free base was treated with HCl to generate the water soluble bis-hyrdochloride salts.
amidines ; benzothiazoles ; furans ; thiophenes ; anti-HIV substances
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Podaci o prilogu
60-60.
2001.
objavljeno
Podaci o matičnoj publikaciji
12th European Symposium on Organic Chemistry : Book of abstracts
Feringa, Ben L.
Groningen:
Podaci o skupu
The 12th European Symposium on Organic Chemistry
poster
13.07.2001-18.07.2001
Groningen, Nizozemska