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Pregled bibliografske jedinice broj: 717881

Identification and Regulation of a Molecular Module for Bleb-Based Cell Motility


Goudarzi, Mehdi; Banisch, Torsten U.; Mobin, Mehrpouya B.; Maghelli, Nicola; Tarbashevich, Katsiaryna; Strate, Ina; van den Berg, Jana; Blaser, Heiko; Bandemer, Sabine; Paluch, Ewa et al.
Identification and Regulation of a Molecular Module for Bleb-Based Cell Motility // Developmental cell, 23 (2012), 1; 210-218 doi:10.1016/j.devcel.2012.05.007 (međunarodna recenzija, članak, znanstveni)


Naslov
Identification and Regulation of a Molecular Module for Bleb-Based Cell Motility

Autori
Goudarzi, Mehdi ; Banisch, Torsten U. ; Mobin, Mehrpouya B. ; Maghelli, Nicola ; Tarbashevich, Katsiaryna ; Strate, Ina ; van den Berg, Jana ; Blaser, Heiko ; Bandemer, Sabine ; Paluch, Ewa ; Bakkers, Jeroen ; Tolić-Norrelykke, Iva Marija ; Raz, Erez

Izvornik
Developmental cell (1534-5807) 23 (2012), 1; 210-218

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Tumor progression; germ-cells; migration; zebrafish; cancer; morphogenesis; annexins; guidance; cadherin; MIR-430
(Tumor progression; germ-cells; migration; zebrafish; cancer; morphogenesis; annexins; guidance; cadherin MIR-430)

Sažetak
Single-cell migration is a key process in development, homeostasis, and disease. Nevertheless, the control over basic cellular mechanisms directing cells into motile behavior in vivo is largely unknown. Here, we report on the identification of a minimal set of parameters the regulation of which confers proper morphology and cell motility. Zebrafish primordial germ cells rendered immotile by knockdown of Dead end, a negative regulator of miRNA function, were used as a platform for identifying processes restoring motility. We have defined myosin contractility, cell adhesion, and cortex properties as factors whose proper regulation is sufficient for restoring cell migration of this cell type. Tight control over the level of these cellular features, achieved through a balance between miRNA-430 function and the action of the RNA-binding protein Dead end, effectively transforms immotile primordial germ cells into polarized cells that actively migrate relative to cells in their environment.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Autor s matičnim brojem:
Iva Marija Tolić, (260543)

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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