engleski

ASSOCIATION OF IL-6 AND TGF-β1 GENE POLYMORPHISMS WITH HIP OSTEOARTHRITIS

Background: Developmental hip dysplasia (DDH) greatly contributes to occurrence of severe hip osteoarthritis (OA) in adulthood, but the association between the two is not a perfect one. Both conditions are known to have a strong genetic component. Transforming growth factor b1 (TGF-b1) and interleukin-6 (IL-6) are two pro-inflammatory cytokines included in pathogenesis of OA, bone remodeling and development of bone and joint tissues. TGF-b1 gene has a polymorphic site in the signal sequence (29T®C) and “C allele carriage” is associated with higher circulating TGF-b1 levels. IL-6 gene has several polymorphic sites in the promoter region including -572T®C transition associated with higher circulating IL-6 levels. We aimed to evaluate a possible association between these polymorphisms and severe adult hip OA secondary to DDH. Methods: Consecutive patients with severe adult hip OA secondary to DDH (requiring hip replacement) (n=68, 22% men, age 27-64 years) and healthy controls (n=20, clinically and radiologically excluded DDH/OA) were genotyped at these loci. Results: With adjustment for sex, “C allele carriage” in the TGF-b1 signal sequence and GG genotype at locus -572 in the IL-6 promoter were each associated with severe OA secondary to DDH (OR=5.94, 95% CI 1.13-31.2, p=0.016 ; and OR=9.91, 95% CI 2.03-48.4, p=0.005 ; respectively). Conclusion: Data from this preliminary analysis support feasibility of larger-scale studies on potential association between TGF-b1 signal sequence and IL-6 promoter polymorphisms and occurrence of DDH and (un)related severe OA.

POLYMORPHISMS; HIP OSTEOARTHRITIS; IL-6; TGF-β1

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