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General theory for the mechanics of confined microtubule asters


Ma, Rui; Laan, Liedewij; Dogterom, Marileen; Pavin, Nenad; Jülicher, Frank
General theory for the mechanics of confined microtubule asters // New journal of physics, 16 (2014), 013018 -1 doi:10.1088/1367-2630/16/1/013018 (međunarodna recenzija, članak, znanstveni)


Naslov
General theory for the mechanics of confined microtubule asters

Autori
Ma, Rui ; Laan, Liedewij ; Dogterom, Marileen ; Pavin, Nenad ; Jülicher, Frank

Izvornik
New journal of physics (1367-2630) 16 (2014); 013018 -1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
caenorhabditis-elegans embryo; cortical dynein; force generators; pulling forces; spindle; position; dynamics; cells; elongation; nuclear

Sažetak
In cells, dynamic microtubules organize into asters or spindles to assist positioning of organelles. Two types of forces are suggested to contribute to the positioning process: (i) microtubule-growth based pushing forces ; and (ii) motor protein mediated pulling forces. In this paper, we present a general theory to account for aster positioning in a confinement of arbitrary shape. The theory takes account of microtubule nucleation, growth, catastrophe, slipping, as well as interaction with cortical force generators. We calculate microtubule distributions and forces acting on microtubule organizing centers in a sphere and in an ellipsoid. Positioning mechanisms based on both pushing forces and pulling forces can be distinguished in our theory for different parameter regimes or in different geometries. In addition, we investigate positioning of microtubule asters in the case of asymmetric distribution of motors. This analysis enables us to characterize situations relevant for Caenorrhabditis elegans embryos.

Izvorni jezik
Engleski



POVEZANOST RADA


Profili:

Avatar Url Nenad Pavin (autor)

Citiraj ovu publikaciju

Ma, Rui; Laan, Liedewij; Dogterom, Marileen; Pavin, Nenad; Jülicher, Frank
General theory for the mechanics of confined microtubule asters // New journal of physics, 16 (2014), 013018 -1 doi:10.1088/1367-2630/16/1/013018 (međunarodna recenzija, članak, znanstveni)
Ma, R., Laan, L., Dogterom, M., Pavin, N. & Jülicher, F. (2014) General theory for the mechanics of confined microtubule asters. New journal of physics, 16, 013018 -1 doi:10.1088/1367-2630/16/1/013018.
@article{article, year = {2014}, pages = {013018 -1-013018 -20}, DOI = {10.1088/1367-2630/16/1/013018}, keywords = {caenorhabditis-elegans embryo, cortical dynein, force generators, pulling forces, spindle, position, dynamics, cells, elongation, nuclear}, journal = {New journal of physics}, doi = {10.1088/1367-2630/16/1/013018}, volume = {16}, issn = {1367-2630}, title = {General theory for the mechanics of confined microtubule asters}, keyword = {caenorhabditis-elegans embryo, cortical dynein, force generators, pulling forces, spindle, position, dynamics, cells, elongation, nuclear} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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