Swinging a sword : how microtubules search for their targets (CROSBI ID 209133)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Pavin, Nenad ; Tolić‑Nørrelykke, Iva M.
engleski
Swinging a sword : how microtubules search for their targets
The cell interior is in constant movement, which is to a large extent determined by microtubules, thin and long filaments that permeate the cytoplasm. To move large objects, microtubules need to connect them to the site of their destination. For example, during cell division, microtubules connect chromosomes with the spindle poles via kinetochores, protein complexes on the chromosomes. A general question is how microtubules, while being bound to one structure, find the target that needs to be connected to this structure. Here we review the mechanisms of how microtubules search for kinetochores, with emphasis on the recently discovered microtubule feature to explore space by pivoting around the spindle pole. In addition to accelerating the search for kinetochores, pivoting helps the microtubules to search for cortical anchors, as well as to self-organize into parallel arrays and asters to target specific regions of the cell. Thus, microtubule pivoting constitutes a mechanism by which they locate targets in different cellular contexts.
microtubules ; kinetochores ; mitosis ; search mechanism ; pivoting ; angular movement
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Podaci o izdanju
8 (3)
2014.
179-186
objavljeno
1872-5325
1872-5333
10.1007/s11693-014-9134-x