Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 715016

Carpal tunnel syndrome is associated with high fibrinogen and fibrinogen deposits


Utrobičić, Ivan; Novak, Ivana; Marinović-Terzić, Ivana; Matić, Katarina; Lessel, Davor; Salamunić, Ilza; Babić Saraga, Mirna; Kunac, Nenad; Mešin Koštić, Anka; Kubisch, Christian et al.
Carpal tunnel syndrome is associated with high fibrinogen and fibrinogen deposits // Neurosurgery, 75 (2014), 3; 276-285 doi:10.1227/NEU.0000000000000422 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 715016 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Carpal tunnel syndrome is associated with high fibrinogen and fibrinogen deposits

Autori
Utrobičić, Ivan ; Novak, Ivana ; Marinović-Terzić, Ivana ; Matić, Katarina ; Lessel, Davor ; Salamunić, Ilza ; Babić Saraga, Mirna ; Kunac, Nenad ; Mešin Koštić, Anka ; Kubisch, Christian ; Maček, Boris ; Terzić, Janoš

Izvornik
Neurosurgery (0148-396X) 75 (2014), 3; 276-285

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Aggregopathy; Carpal tunnel syndrome; Fibrinogen

Sažetak
Idiopathic carpal tunnel syndrome (ICTS) is a common entrapment neuropathy. Some cases of ICTS are linked to mutations of the transthyretin gene, whereas others are associated with systemic amyloidosis. The majority of ICTS cases are of unknown etiology. Ovjective was to study molecular mechanisms of ICTS development. A total of 71 ICTS patients and 68 control subjects were included in the study. The fibrinogen level was determined before surgery and its deposition in the transversal carpal ligament (TCL) was detected by immunohistochemistry, Western blot, and mass spectrometry. Fibrinogen interaction with other proteins was studied by immunoprecipitation assay. Plasma levels of the proinflammatory and hemostatic protein fibrinogen are elevated in ICTS patients. Other measured systemic inflammatory markers were not affected, and local inflammatory responses in TCL were absent. ICTS patients have shorter bleeding times, probably because of the elevated plasma levels of fibrinogen. Polymorphisms of the fibrinogen B promoter region were previously associated with increased plasma fibrinogen, but this association was not observed among patients with ICTS. Interestingly, we detected fibrinogen deposits in the TCL, whereas transcriptional activity of the fibrinogen genes was low. Amyloidogenic proteins, including transthyretin and α-synuclein, were also found in the TCL, whereas their local transcriptional activity was rather high. Finally, we demonstrated that fibrinogen interacts with transthyretin and α-synuclein in TCL lysates. Our data indicate that fibrinogen and other aggregation-prone proteins have potentially important roles in the pathogenesis of ICTS.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
KBC Split

Citiraj ovu publikaciju

Utrobičić, Ivan; Novak, Ivana; Marinović-Terzić, Ivana; Matić, Katarina; Lessel, Davor; Salamunić, Ilza; Babić Saraga, Mirna; Kunac, Nenad; Mešin Koštić, Anka; Kubisch, Christian et al.
Carpal tunnel syndrome is associated with high fibrinogen and fibrinogen deposits // Neurosurgery, 75 (2014), 3; 276-285 doi:10.1227/NEU.0000000000000422 (međunarodna recenzija, članak, znanstveni)
Utrobičić, I., Novak, I., Marinović-Terzić, I., Matić, K., Lessel, D., Salamunić, I., Babić Saraga, M., Kunac, N., Mešin Koštić, A. & Kubisch, C. (2014) Carpal tunnel syndrome is associated with high fibrinogen and fibrinogen deposits. Neurosurgery, 75 (3), 276-285 doi:10.1227/NEU.0000000000000422.
@article{article, year = {2014}, pages = {276-285}, DOI = {10.1227/NEU.0000000000000422}, keywords = {Aggregopathy, Carpal tunnel syndrome, Fibrinogen}, journal = {Neurosurgery}, doi = {10.1227/NEU.0000000000000422}, volume = {75}, number = {3}, issn = {0148-396X}, title = {Carpal tunnel syndrome is associated with high fibrinogen and fibrinogen deposits}, keyword = {Aggregopathy, Carpal tunnel syndrome, Fibrinogen} }
@article{article, year = {2014}, pages = {276-285}, DOI = {10.1227/NEU.0000000000000422}, keywords = {Aggregopathy, Carpal tunnel syndrome, Fibrinogen}, journal = {Neurosurgery}, doi = {10.1227/NEU.0000000000000422}, volume = {75}, number = {3}, issn = {0148-396X}, title = {Carpal tunnel syndrome is associated with high fibrinogen and fibrinogen deposits}, keyword = {Aggregopathy, Carpal tunnel syndrome, Fibrinogen} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font